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Carbamazepine-viloxazine interaction in patients with epilepsy.

Author: Di PerriR, FazioA, OteriG, PeruccaE, PisaniB, PisaniF, RussoM, TrioR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Viloxazine, an antidepressant agent, induced a significant increase in steady-state plasma carbamazepine concentration in six depressed epileptic patients. The increase was associated with symptoms of carbamazepine intoxication in three patients.
Paper Details　
Original Abstract of the Article :
In six depressed epileptic patients stabilised on carbamazepine therapy, addition of the antidepressant agent viloxazine (300 mg/day for three weeks) induced a marked (average 55%) increase in steady-state plasma carbamazepine concentration. The concentration of the active metabolite carbamazepine-1...See full text at original site
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引用元：
https://doi.org/10.1136/jnnp.49.10.1142

データ提供：米国国立医学図書館（NLM）

Carbamazepine-Viloxazine Interaction: A Desert Oasis or a Hidden Danger?

This study investigates the interaction between carbamazepine, a medication used for treating epilepsy, and viloxazine, an antidepressant. It's like a desert explorer investigating the potential benefits and risks of combining two different desert plants. The study finds that viloxazine can significantly increase the levels of carbamazepine in the blood, potentially leading to intoxication. It's like a desert oasis that can turn into a dangerous mirage, leading to unexpected consequences.

Carbamazepine-Viloxazine Interaction: A Cautionary Tale in the Desert

The study highlights the importance of careful monitoring and caution when prescribing viloxazine to patients already taking carbamazepine. It's like navigating a desert with a keen awareness of potential hazards, adjusting your course as needed.

Navigating the Desert of Medication Interactions: A Multidisciplinary Approach

This research emphasizes the need for close collaboration between physicians and pharmacists to ensure safe and effective medication use. It's like a desert expedition that requires the expertise of both navigators and guides to ensure a successful journey.

Dr.Camel's Conclusion

This research serves as a cautionary tale about medication interactions, reminding us that even seemingly benign combinations can lead to unexpected consequences. It's like a desert oasis that can be both beautiful and treacherous. Always consult with your healthcare provider before making any changes to your medication regimen.

Date :
  1. Date Completed 1986-12-30
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

3783175

DOI: Digital Object Identifier

10.1136/jnnp.49.10.1142

Related Literature

Article Analysis
・Side Effects of viloxazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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