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[In vitro Activity of Rifabutin and Clofazimine to Macrolide-Resistant Mycobacterium abscessus Complex Clinical Isolates].

Author: GaziHörü, SürücüoğluSüheyla, ÇavuşoğluCengiz, ÖzkütükNuri

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the in vitro activity of rifabutin and clofazimine against clinical isolates of Mycobacterium abscessus complex (MABSC) resistant to macrolides. Rifabutin showed higher MIC values in isolates with macrolide resistance, suggesting the need for susceptibility testing before using it in treatment. Clofazimine exhibited low MIC values in all strains, making it a potential first-choice drug in combination therapy.
Paper Details　
Original Abstract of the Article :
Mycobacterium abscessus complex (MABSC) is one of the most resistant bacteria against antimicrobial agents. The number of agents that can be used by oral route, such as macrolides, is limited in antimicrobial therapy. In recent years, rifabutin and clofazimine have gained importance as they can be a...See full text at original site
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引用元：
https://doi.org/10.5578/mb.20239951

データ提供：米国国立医学図書館（NLM）

Combating Drug-Resistant Mycobacterium abscessus Complex: Finding New Weapons in the Arsenal

This research delves into the [challenges] of treating [Mycobacterium abscessus complex (MABSC)], a [highly resistant bacteria] that poses a significant threat to human health. It's like trying to conquer a fortress in the desert, where every attack must be carefully planned and executed. The authors investigate the [in vitro activity] of [rifabutin] and [clofazimine] against [macrolide-resistant MABSC clinical isolates].

A Promising New Front in the Fight Against MABSC

The study found that [clofazimine] exhibited [high activity] against [MABSC] isolates, even those resistant to [macrolides]. This is like finding a hidden spring in the desert, a source of relief in a parched landscape. The authors suggest that [clofazimine] could be a valuable addition to [MABSC] treatment regimens.

Hope for Improved Treatment Outcomes for MABSC Infections

This research offers hope for improved [treatment] outcomes for patients with [MABSC] infections. It's like discovering a new path through the desert, leading to a more effective approach to combating this challenging infection. The authors emphasize the need for further studies to optimize [treatment] strategies for [MABSC] infections.

Dr.Camel's Conclusion

This study is a testament to the ongoing quest to find new and effective solutions for [drug-resistant infections]. It's like venturing into a vast and unforgiving desert, where every discovery is a victory. The authors' findings are like a shimmering oasis, offering hope for patients battling this challenging condition.

Date :
  1. Date Completed 2023-10-30
  2. Date Revised 2023-10-30
Further Info :

Pubmed ID

37885391

DOI: Digital Object Identifier

10.5578/mb.20239951

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SNS
PICO Info
in preparation
Languages

Turkish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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