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Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia.

Author: ChenHaiying, ChenHuimin, DaiZihao, DuYiqi, GaoYunjie, GeZhizheng, GongShuai, LiXiaobo, LiZhaoshen, LiuSide, LuHong, LuLungen, ShenXizhong, ShenYufeng, TangMingyu, WuShan, XiongHua, XuLeiming, XueHanbing, YangAiming, YangShiming, ZhangQingwei, ZhaoRan, ZhongJie, ZhongLiang

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Thalidomide was effective in reducing bleeding in patients with recurrent bleeding due to small-intestinal angiodysplasia (SIA). Treatment with thalidomide at a daily dose of 100 mg resulted in a 68.6% effective response, compared to 51.0% for 50 mg thalidomide and 16.0% for placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Recurrent bleeding from the small intestine accounts for 5 to 10% of cases of gastrointestinal bleeding and remains a therapeutic challenge. Thalidomide has been evaluated for the treatment of recurrent bleeding due to small-intestinal angiodysplasia (SIA), but confirmatory trials are la...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa2303706

データ提供：米国国立医学図書館（NLM）

Thalidomide: A Promising Remedy for Small-Intestinal Angiodysplasia

Small-intestinal angiodysplasia (SIA), a condition characterized by abnormal blood vessels in the small intestine, can cause recurrent and often severe bleeding. This research investigates the efficacy and safety of thalidomide, a medication typically used for other conditions, in treating recurrent bleeding due to SIA. The researchers conducted a double-blind, placebo-controlled trial to evaluate the impact of thalidomide on reducing bleeding episodes in patients with SIA. The study found that thalidomide significantly reduced the number of bleeding episodes in patients with SIA, offering a potential treatment option for this challenging condition.

Thalidomide: A Potential Solution for Recurrent Bleeding

The study concluded that thalidomide was effective in reducing bleeding episodes in patients with recurrent bleeding due to SIA. The results showed a significantly higher percentage of patients experiencing a reduction in bleeding episodes in the thalidomide group compared to the placebo group. This finding suggests that thalidomide could be a valuable treatment option for patients with SIA.

Navigating Potential Side Effects

While thalidomide shows promise for treating SIA, it's important to remember that it can have potential side effects. It's crucial to discuss your medical history and any concerns with your doctor before starting thalidomide treatment to ensure it's a safe and appropriate option for you.

Dr. Camel's Conclusion

Recurrent bleeding due to SIA can be a challenging and disruptive condition. This research provides a beacon of hope, suggesting that thalidomide may offer a new approach to managing this condition. Remember, always consult with a qualified healthcare professional before starting any new medication to ensure its safety and effectiveness for your individual needs.
Date :
  1. Date Completed 2023-11-03
  2. Date Revised 2023-11-03
Further Info :

Pubmed ID

37913505

DOI: Digital Object Identifier

10.1056/NEJMoa2303706

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Article Analysis
・Effective treatment of gastrointestinal bleeding
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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