Ubrogepant for the treatment of migraine attacks during the prodrome: a phase 3, multicentre, randomised, double-blind, placebo-controlled, crossover trial in the USA.

Author: DodickDavid W, FinneganMichelle, GoadsbyPeter J, LiptonRichard B, LiuChengcheng, LuKaifeng, SchwedtTodd J, SevertLawrence, TrugmanJoel M, YuSung Yun

Paper Details 
Original Abstract of the Article :
Ubrogepant is a calcitonin gene-related peptide (CGRP) receptor antagonist that is approved for acute treatment of migraine. The prodrome is the earliest phase of a migraine attack and is characterised by non-aura symptoms that precede headache onset. The aim of this trial was to evaluate the effica...See full text at original site
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引用元:
https://doi.org/10.1016/S0140-6736(23)01683-5

データ提供:米国国立医学図書館(NLM)

Ubrogepant: A New Approach to Migraine Treatment

Migraine, a debilitating condition affecting millions worldwide, can be incredibly disruptive. This study explores the potential of a new medication, ubrogepant, for treating migraines during the prodrome phase, the early stage characterized by pre-headache symptoms. The drug is a CGRP receptor antagonist, meaning it blocks the action of a protein implicated in migraine pain. Researchers conducted a double-blind, placebo-controlled trial, evaluating the effectiveness of ubrogepant compared to a placebo in treating migraine attacks during the prodrome.

Ubrogepant: A Promising Treatment Option for Migraine

The study found that ubrogepant, when administered during the prodrome, was effective in treating migraine attacks. This suggests that the drug could be a valuable tool for managing migraine, potentially preventing the onset of severe headaches or reducing their intensity. Further research is needed to determine the long-term effects and optimal usage of ubrogepant.

Managing Migraine: Early Intervention is Key

This study underscores the importance of early intervention in migraine treatment. By targeting the prodrome phase, ubrogepant may help prevent the escalation of pain and discomfort. This could potentially improve the lives of migraine sufferers and allow them to manage their condition more effectively.

Dr. Camel's Conclusion

This research offers a glimmer of hope for migraine sufferers, highlighting the potential of ubrogepant to ease the burden of this debilitating condition. It's like finding a hidden oasis in the vast desert of migraine pain, offering relief and a renewed sense of well-being.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-18
Further Info :

Pubmed ID

37979595

DOI: Digital Object Identifier

10.1016/S0140-6736(23)01683-5

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