Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.

Author: Abdelrahim SaeedMohammed, Ahmed AliMujahid, AlvarJorge, AlvesFabiana, Awad Gasim KhalilEltahir, ChuWan-Yu, DorloThomas P C, EgondiThaddaeus, Elbashir AhmedAnas, MmboneMildred, MonneratSéverine, Mudawi MusaAhmed, Muthoni OuattaraGina, NoureldinAli, NyakayaGodfrey M, OchiengMichael, OmolloTruphosa, TeshomeSamuel, WasunnaMonique, YounisBrima Musa, ZijlstraEduard E

Paper Details 
Original Abstract of the Article :
Treatment for post-kala-azar dermal leishmaniasis (PKDL) in Sudan is currently recommended only for patients with persistent or severe disease, mainly because of the limitations of current therapies, namely toxicity and long hospitalization. We assessed the safety and efficacy of miltefosine combine...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/37988402

データ提供:米国国立医学図書館(NLM)

A Promising New Treatment for Post-Kala-Azar Dermal Leishmaniasis

This study explores the challenging world of tropical medicine, focusing on the development of new treatments for post-kala-azar dermal leishmaniasis (PKDL). PKDL is a skin infection caused by the parasite Leishmania, which can occur after a person has been infected with visceral leishmaniasis (kala-azar). The researchers investigated the safety and efficacy of a combination therapy that included miltefosine, paromomycin, and liposomal amphotericin B. This new treatment is like a caravan of powerful medications, working together to combat the parasite and improve patient outcomes.

A New Approach to Treating PKDL

The researchers found that the combination therapy was safe and effective in treating PKDL. This is an important discovery, as current treatments for PKDL often have significant side effects and require long hospital stays. This new therapy could offer a more convenient and tolerable option for patients.

A Hope for the Future

This research is a beacon of hope in the vast desert of tropical medicine. It provides promising evidence that a new and effective treatment for PKDL is within reach. This could have a profound impact on the lives of patients in regions where PKDL is endemic.

Dr.Camel's Conclusion

This study offers a glimmer of hope in the fight against post-kala-azar dermal leishmaniasis. By developing new and effective treatments, we can improve the lives of patients suffering from this debilitating disease. This is a testament to the power of research and the dedication of medical professionals working to overcome the challenges of tropical medicine.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-14
Further Info :

Pubmed ID

37988402

DOI: Digital Object Identifier

PNTD-D-23-00386

Related Literature

SNS
PICO Info
in preparation
Languages

English

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