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A novel SPE-LC-MRM strategy for serum demethylzeylasteral quantitation developed with an <sup>18</sup>O-labeled internal standard.

Author: DangXin, GengYi-Cong, HePing, KongLing-Fei, LiZheng-Ying, MaoYong-Hui, TieCai, WangYi, ZhaoBan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study presents a novel quantitation method for analyzing demethylzeylasteral, a natural bioactive compound derived from Tripterygium wilfordii Hook f., in serum. The method utilizes <sup>18</sup>O labeling and off-line SPE, demonstrating high accuracy, precision, and recovery, offering a valuable tool for clinical research and therapeutic drug monitoring.
Paper Details　
Original Abstract of the Article :
Natural bioactive compounds (NBCs) are widely used in clinical treatment. For example, Tripterygium wilfordii Hook f. is commonly known in China as Lei-Gong-Teng which means thunder god vine. This herb is widely distributed in Eastern and Southern China, Korea, and Japan. The natural bioactive compo...See full text at original site
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引用元：
https://doi.org/10.1007/s00216-023-05049-z

データ提供：米国国立医学図書館（NLM）

Quantifying Demethylzeylasteral: A Camel's Journey Through Drug Metabolism

The world of natural bioactive compounds (NBCs) is a treasure trove of potential therapies. This research focuses on demethylzeylasteral, a compound found in the herb Tripterygium wilfordii Hook f. (Thunder God Vine), which has been used in traditional Chinese medicine for centuries. It's like exploring a vast desert for hidden medicinal gems.

The researchers developed a novel method to accurately quantify demethylzeylasteral in serum, overcoming the challenges of matrix effects and complex isotope internal standard synthesis. This research is like finding a map to the oasis of accurate drug measurement, helping to guide us through the intricacies of drug metabolism.

A Map to the Oasis of Accurate Drug Measurement

The new quantitation method developed in this study is a significant advancement, improving the accuracy of drug monitoring and paving the way for better clinical applications.

A Camel's Guide to Natural Remedies

As a wise camel, I always appreciate the value of natural remedies. This research offers a glimpse into the potential of Thunder God Vine and its ability to help patients.

Dr. Camel's Conclusion

This research is a testament to the power of innovation and the value of traditional medicine. It's like finding a new path through the desert of drug development, leading us toward a more precise and effective understanding of drug metabolism.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-22
Further Info :

Pubmed ID

37993551

DOI: Digital Object Identifier

10.1007/s00216-023-05049-z

Related Literature

Article Analysis
・Effective treatment of thunder god vine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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