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Systemic and targeted steroids for the treatment of IgA nephropathy.

Author: Del VecchioLucia, LocatelliFrancesco, PonticelliClaudio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the treatment of immunoglobulin A nephropathy (IgAN), a common glomerulonephritis. While many treatments have been used, uncertainty remains regarding their effectiveness and ideal doses. Systemic glucocorticoids can be effective for patients with persistent proteinuria but can cause systemic side effects. The article highlights the potential of targeted-release formulation (TRF) budesonide, a novel approach to reduce the adverse events of systemic steroids. Two clinical trials showed promising results, with TRF budesonide significantly reducing proteinuria and haematuria while preserving renal function. However, more long-term data is needed before TRF budesonide can be considered a standard of care treatment for IgAN.
Paper Details　
Original Abstract of the Article :
Immunoglobulin A nephropathy (IgAN) is a common glomerulonephritis partially correlated with mucosal immune system dysfunction. Progressive renal failure occurs in many patients, with about 30-50% of the patients with IgAN developing end-stage kidney disease (ESKD). Many treatments have been used fo...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695509/

データ提供：米国国立医学図書館（NLM）

Treating IgA Nephropathy: Seeking New Solutions

IgA nephropathy, a kidney disease, is like a desert sandstorm, gradually eroding the kidneys' ability to function. This research explores the treatment options for IgA nephropathy, searching for effective solutions to prevent further kidney damage. It's like searching for a spring in the desert, desperately seeking a way to replenish and sustain life. The researchers discuss the use of steroids, both systemic and targeted, to manage the condition. They acknowledge the potential benefits of these treatments but also highlight the need for careful monitoring and a balanced approach.

Steroids: A Double-Edged Sword in Treating IgA Nephropathy

The research explores the use of steroids, both systemic and targeted, in managing IgA nephropathy. It's like trying to tame a desert storm with different approaches, each with its own strengths and weaknesses. While steroids can effectively reduce proteinuria, they can also have significant side effects.

A Promising Future for Targeted Therapies

The research highlights the potential of targeted therapies, such as budesonide, to reduce the side effects of steroids while still effectively treating IgA nephropathy. It's like finding a more precise way to navigate the desert, minimizing risk and maximizing benefit.

Dr.Camel's Conclusion

This research sheds light on the complex challenges of treating IgA nephropathy, a disease that often requires a multifaceted approach. It's a reminder that finding effective and safe solutions requires continued research and a commitment to developing innovative therapies. It's like navigating a vast and challenging desert, constantly seeking new pathways to health and well-being.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-07
Further Info :

Pubmed ID

38053978

DOI: Digital Object Identifier

PMC10695509

Related Literature

Article Analysis
・Side Effects of budesonide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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