Side Effects of budesonide: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Main Research Findings

Budesonide, a corticosteroid medication, is often used to treat various inflammatory conditions, including Crohn's disease, allergic rhinitis, asthma, and autoimmune hepatitis. While generally effective, budesonide, like other corticosteroids, can cause a range of side effects. 7 、 12 、、 14 、 10

Reasons for Side Effects

Budesonide's side effects stem from its mechanism of action, mimicking the effects of the steroid hormone cortisol. Cortisol plays a crucial role in various bodily functions, including immune system suppression, blood sugar regulation, bone metabolism, and electrolyte balance. Budesonide, due to its structural similarity to cortisol, can trigger these effects, potentially leading to side effects. 、 13

Common Side Effects

Mental Side Effects

Budesonide has been linked to mental side effects, including depression, anxiety, insomnia, hallucinations, and manic episodes.

Gastrointestinal Side Effects

Budesonide can lead to gastrointestinal side effects such as stomach ulcers, peptic ulcers, malabsorption, and gastrointestinal bleeding. 13

Osteoporosis

Budesonide may hinder bone formation and reduce bone density, increasing the risk of osteoporosis. 3 、 13

Hyperglycemia

Budesonide can elevate blood sugar levels, potentially raising the risk of developing diabetes. 13

Immunosuppression

Budesonide's suppression of the immune system can increase the vulnerability to infections. 13

Other

Besides the aforementioned side effects, budesonide can also cause weight gain, edema, muscle weakness, skin thinning, cataracts, and glaucoma. 13

Measures to Counter Side Effects

Mental Side Effects

If you experience mental side effects, seek medical advice and consider discontinuing the medication or switching to an alternative treatment.

Gastrointestinal Side Effects

If you experience gastrointestinal side effects, consult your doctor and consider discontinuing the medication or switching to an alternative treatment. 13

Osteoporosis

To reduce the risk of osteoporosis, ensure adequate calcium and vitamin D intake and engage in regular exercise. Your doctor may recommend osteoporosis medications if necessary. 3 、 13

Hyperglycemia

To mitigate the risk of hyperglycemia, adopt dietary changes, engage in physical activity, and manage your blood sugar levels. If necessary, your doctor may prescribe diabetes medications. 13

Immunosuppression

To reduce the risk of infections related to immunosuppression, practice good hygiene such as handwashing and undergo regular health checks. Your doctor may suggest vaccinations if necessary. 13

Comparison Between Studies

Commonalities

Multiple studies have demonstrated the efficacy of budesonide in treating inflammatory diseases. However, due to its potential for systemic absorption, budesonide can cause a range of side effects. 1 、 12 、、 3 、 13 、 8 、 6 、 5 、 11 、 10 、 9

Differences

The side effects of budesonide can vary among individuals and depend on the specific condition being treated and the method of administration. For instance, inhaled budesonide may lead to fewer gastrointestinal side effects but a higher risk of respiratory side effects. Long-term use of budesonide increases the likelihood of osteoporosis. 1 、 12 、、 3 、 13 、 8 、 6 、 5 、 11 、 10 、 9

Points to Note for Applying the Research to Real Life

While budesonide proves effective in treating various inflammatory diseases, it's crucial to be aware of its potential side effects. When considering budesonide, consult your doctor and select a treatment plan that aligns with your individual needs. 12 、、 14 、 10

Limitations of Current Research

The complete range of side effects associated with budesonide remains unclear. Further research is needed, especially concerning long-term side effects. 7 、 12 、、 14 、 10

Directions for Future Research

Further research is needed to thoroughly understand the side effects of budesonide and develop ways to minimize their occurrence. The development of new treatments to reduce the side effects of budesonide is also a promising area for future research. 7 、 12 、、 14 、 10

Conclusion

Budesonide is an effective medication for treating a variety of inflammatory diseases, but it is important to be aware of its potential side effects. If you are considering budesonide, consult your doctor and make sure to select a treatment plan that is right for you. 12 、、 14 、 10

Literature analysis of 15 papers
Positive Content
13
Neutral Content
1
Negative Content
1
Article Type
5
0
0
6
15
1.

A comparison of budesonide with prednisolone for active Crohn's disease.

Author: RutgeertsP, LöfbergR, MalchowH, LamersC, OlaisonG, JewellD, DanielssonA, GoebellH, ThomsenO O, Lorenz-MeyerH

Crohn's disease remission
Reduced side effects
Abdominal-wall fistula
Intestinal perforation

Budesonide and prednisolone were both effective in inducing remission in Crohn's disease patients. Budesonide was associated with fewer glucocorticoid-associated side effects and less suppression of pituitary-adrenal function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Study on serum and urinary cortisol levels of asthmatic patients after treatment with high dose inhaled beclomethasone dipropionate or budesonide.

Author: KaurCharanjeet, BansalS K, ChhabraS K

Asthma treatment
HPA axis suppression

Inhaled corticosteroids can be absorbed systemically, potentially leading to adverse effects. The study compared beclomethasone dipropionate (BDP) and budesonide (BUD) and found that they had similar effects on HPA axis suppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.

Author: SchoonErik J, BollaniSimona, MillsPeter R, IsraeliEran, FelsenbergDieter, LjunghallSverker, PerssonTore, Haptén-WhiteLouise, GraffnerHans, Bianchi PorroGabriele, VatnMorten, StockbrüggerReinhold W,

Preserve bone mass
Reduce corticosteroid side effects

Budesonide treatment preserves bone mass better than prednisolone in corticosteroid-naive patients with active ileocecal Crohn's disease. Both treatments are equally effective in both corticosteroid-free and corticosteroid-dependent groups, but budesonide causes fewer corticosteroid side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC.

Author: GeierAndreas, GartungCarsten, DietrichChristoph G, WasmuthHermann E, ReinartzPatrick, MaternSiegfried

Side effects

Serum budesonide levels can be significantly increased in patients with Child A cirrhosis due to autoimmune hepatitis, potentially leading to systemic side effects. Reduced hepatic metabolism, rather than portosystemic shunting, may explain these side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Comparison of the efficacy and side effects of aqueous steroid nasal spray (budesonide) and allergen-injection therapy (Pollinex-R) in the treatment of seasonal allergic rhinoconjunctivitis.

Author: JuniperE F, KlineP A, RamsdaleE H, HargreaveF E

Effective for rhinitis
Systemic reactions

Budesonide aqueous nasal spray was markedly more effective than Pollinex-R in controlling symptoms of seasonal rhinitis. Budesonide was well-tolerated with no clinically important side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Corticosteroid therapy in IgA Nephropathy: A friend or foe?

Author: KimDana, WongMuh Geot

IgAN treatment
Side effects

This review discusses the controversial use of corticosteroids in the management of immunoglobulin A nephropathy (IgAN). The lack of well-designed randomized controlled trials and concerns about corticosteroid side effects contribute to the ongoing debate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Budesonide as first-line treatment in patients with autoimmune hepatitis seems inferior to standard predniso(lo)ne administration.

Author: Díaz-GonzálezÁlvaro, Hernández-GuerraManuel, Pérez-MedranoIndhira, SapenaVíctor, Riveiro-BarcielaMar, Barreira-DíazAna, GómezElena, MorillasRosa M, Del BarrioMaría, EscudéLaia, MateosBeatriz, HortaDiana, GómezJudith, CondeIsabel, Ferre-AracilCarlos, El HajraIsmael, ArencibíaAna, ZamoraJavier, FernándezAinhoa, SalcedoMagdalena, MolinaEsther, SoriaAnna, EstévezPamela, LópezCarmen, Álvarez-NavascúesCarmen, García-RetortilloMontserrat, CrespoJavier, LondoñoMaría-Carlota,

AIH treatment

This study examined the use of budesonide compared to prednisone as first-line treatments for non-severe autoimmune hepatitis (AIH) without cirrhosis. While clinical guidelines suggest both drugs, budesonide is rarely used. The study aimed to describe its use and compare efficacy and safety.

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A Randomized Comparison of Effects of Budesonide Spray and K-Y Gel as an Endotracheal Tube Cuff Lubricant on Incidence of Postoperative Sore Throat.

Author: HintongThanoo, ChongvisalSasawat, PipanmekapornTanyong, UnchitiKantarakorn

POST prevention

Budesonide spray on the endotracheal tube cuff is a simple and effective alternative to preinduction inhalation for preventing postoperative sore throat (POST) and can be implemented for most patients requiring endotracheal intubation.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

New Versus Old: The Impact of Changing Patterns of Inhaled Corticosteroid Prescribing and Dosing Regimens in Asthma Management.

Author: SinghDave, GarciaGabriel, ManeechotesuwanKittipong, Daley-YatesPeter, IrusenElvis, AggarwalBhumika, BoucotIsabelle, BerendNorbert

Asthma control
Cortisol suppression

This review examines the efficacy and systemic activity of different budesonide and fluticasone propionate dosing regimens for asthma management, concluding that regular daily inhaled corticosteroid dosing offers greater bronchoprotection than as-needed regimens while maintaining low systemic activity, but adherence to regular daily dosing is crucial for optimal benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Current status of glucocorticoid usage in solid organ transplantation.

Author: Dashti-KhavidakiSimin, SaidiReza, LuHong

Improved transplant outcomes
Reduced rejection
Bone problems
Cardiovascular problems
Gastrointestinal problems
Neuromuscular problems
Skin problems

This review discusses the use of glucocorticoids (GCs) in solid organ transplantation (SOT). GCs are a type of steroid that can suppress the immune system. The review found that GCs have both benefits and risks in SOT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Glucocorticoid Therapy in Inflammatory Bowel Disease: Mechanisms and Clinical Practice.

Author: BruscoliStefano, FeboMarta, RiccardiCarlo, MiglioratiGraziella

Glucocorticoids
IBD Treatment
Adverse Drug Effects

This review discussed the efficacy of first- and second-generation glucocorticoids (GCs) in treating inflammatory bowel disease (IBD). While second-generation GCs have shown promise, they are still associated with adverse effects. The need for new GC mediators, such as glucocorticoid-induced leucine zipper, to separate benefits from detrimental effects is highlighted.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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