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Does sacubitril/valsartan work in children with heart failure?-a pilot study.

Author: ChenXi, ChenYijun, GongXiaolei, LiuLiping, SongWenting, XuYahe, XuZhuoming, ZhangMingjie, ZhangYuqi, ZhuLimin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This pilot study evaluated the safety and effectiveness of sacubitril/valsartan in children with heart failure (HF). The goal is to understand how this medication works in this population.
Paper Details　
Original Abstract of the Article :
Sacubitril/valsartan is an angiotensin receptor neprilysin antagonist (ARNI) approved for adult heart failure (HF). Its safety and efficacy in pediatric HF patients with cardiomyopathy or congenital heart disease are poorly understood. A pilot study was conducted to assess the clinical response, eff...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716201/

データ提供：米国国立医学図書館（NLM）

Sacubitril/Valsartan in Pediatric Heart Failure: A New Oasis in the Desert?

Heart failure is a serious condition that can affect people of all ages, including children. Sacubitril/valsartan, a medication commonly used in adults with heart failure, has shown promise, but its safety and efficacy in pediatric patients remain largely unexplored. This pilot study aimed to investigate the potential benefits and risks of sacubitril/valsartan in children with heart failure, like exploring a new oasis in the desert of pediatric cardiology, seeking ways to improve the health and well-being of young patients.

Early Insights into Sacubitril/Valsartan's Potential

The pilot study, involving a small group of children with heart failure, provided preliminary insights into the safety and clinical response to sacubitril/valsartan. While further research is needed to confirm its effectiveness in this population, the study's findings offer a glimmer of hope, like discovering a small oasis in a vast and unforgiving desert.

The Future of Pediatric Heart Failure Treatment

This pilot study serves as a crucial stepping stone in the ongoing quest to develop effective treatments for pediatric heart failure. It's a reminder that the desert of medical research is vast and challenging, but the potential rewards are immense. By carefully exploring new therapeutic options and conducting rigorous clinical trials, we can create a more hopeful future for children facing this debilitating condition.

Dr.Camel's Conclusion

This pilot study provides a valuable starting point for investigating the potential benefits and risks of sacubitril/valsartan in pediatric heart failure. It's a reminder that the search for effective treatments for complex medical conditions is an ongoing journey, requiring patience, perseverance, and a willingness to explore new paths. The desert of medical research is vast, but with careful exploration and a commitment to innovation, we can discover new oases that offer hope for a healthier future for all.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-14
Further Info :

Pubmed ID

38094112

DOI: Digital Object Identifier

PMC10716201

Related Literature

Article Analysis
・Side Effects of valsartan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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