The mutagenic activity of anti-cancer drugs and the urine of rats given these drugs.

Author: IwasakiT, MiyakawaM, PakK, YoshidaO

Paper Details 
Original Abstract of the Article :
Twenty-one anti-cancer drugs have been tested for their ability to cause mutations in Salmonella typhimurium test strains in the Salmonella/microsome mutagenicity test. Nine of the 21 anticancer drugs showed this ability: cyclophosphmide, nitromin, thio-tepa, busulfan, 6-mercaptopurine, neocarzinost...See full text at original site
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引用元:
https://doi.org/10.1007/BF00254692

データ提供:米国国立医学図書館(NLM)

Anticancer Drugs: Exploring their Mutagenic Potential

This study investigates the mutagenic activity of various anticancer drugs using the Salmonella/microsome mutagenicity test. The researchers tested 21 drugs for their ability to cause mutations in Salmonella typhimurium strains. They also investigated the mutagenic potential of urine from rats treated with these drugs.

Anticancer Drugs' Mutagenic Activity: A Double-Edged Sword

The study found that nine out of the 21 anticancer drugs tested exhibited mutagenic activity. The urine from rats treated with six of these drugs also showed mutagenic properties, highlighting the potential for these drugs to induce genetic changes.

Anticancer Therapy: A Balancing Act Between Benefits and Risks

This research provides valuable insights into the potential mutagenic effects of anticancer drugs. It emphasizes the importance of considering both the therapeutic benefits and potential risks of these drugs.

Dr. Camel's Conclusion

Just like a camel navigates a treacherous desert, anticancer drugs can be powerful tools for fighting cancer, but they also carry potential risks. This study reminds us that even while seeking a cure, we must be aware of the potential side effects and strive to find the most effective and safest treatment options.

Date :
  1. Date Completed 1979-10-24
  2. Date Revised 2019-09-11
Further Info :

Pubmed ID

382571

DOI: Digital Object Identifier

10.1007/BF00254692

Related Literature

SNS
PICO Info
in preparation
Languages

English

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