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Effect of metoclopramide and bethanechol on gastric emptying in infants.

Author: AbramsC, DuboisA, HymanP E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Metoclopramide (1 mg/kg IV) significantly increased gastric emptying rate in 8 out of 10 infants with gastrointestinal motor disorders compared to bethanechol (0.075 mg/kg SC). No side effects were reported.
Paper Details　
Original Abstract of the Article :
In a double-blind, placebo controlled study of 10 infants with upper gastrointestinal motor disorders, metoclopramide (1 mg/kg, intravenous) but not bethanechol (0.075 mg/kg, subcutaneous), significantly increased the fractional rate of gastric emptying following a 5% glucose meal. Infants were test...See full text at original site
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引用元：
https://doi.org/10.1203/00006450-198510000-00016

データ提供：米国国立医学図書館（NLM）

Metoclopramide: A Potential Treatment for Delayed Gastric Emptying in Infants

Imagine a tiny camel struggling to digest its food, unable to move it through its system. This is similar to what happens when infants experience delayed gastric emptying, a condition that can cause discomfort and feeding difficulties. This study explores the potential of metoclopramide, a medication that promotes digestion, as a treatment for delayed gastric emptying in infants. The researchers conducted a study comparing the effects of metoclopramide and bethanechol, another medication that can affect digestion, on infants with delayed gastric emptying. They found that metoclopramide, like a gentle hand guiding the camel's food through its system, effectively increased the rate of gastric emptying in infants, suggesting its potential as a treatment for this condition.

Metoclopramide: A Promising Solution for Infant Digestion Issues

This study highlights the potential of metoclopramide as a treatment for delayed gastric emptying in infants. The researchers found that metoclopramide effectively increased the rate of gastric emptying, suggesting its potential as a safe and effective solution for this condition. This research offers hope for parents struggling with infants who experience feeding difficulties due to delayed gastric emptying.

Understanding the Complexities of Infant Digestion

This study underscores the importance of understanding the complexities of infant digestion. Just as a desert traveler needs to know the best routes to navigate the terrain, healthcare professionals need to understand the intricacies of infant digestion to provide effective treatment. This research contributes to our understanding of infant digestive disorders, offering valuable insights for future treatment development.

Dr.Camel's Conclusion

This study offers a ray of hope for parents navigating the challenges of delayed gastric emptying in infants. Metoclopramide, like a skilled guide leading a camel through the desert, can help infants digest their food more effectively, potentially leading to a smoother and more comfortable experience. This research serves as a reminder of the ongoing efforts to understand and treat digestive disorders, especially in our most vulnerable populations.

Date :
  1. Date Completed 1985-11-26
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

3903644

DOI: Digital Object Identifier

10.1203/00006450-198510000-00016

Related Literature

Article Analysis
・Side Effects of bethanechol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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