[Fundamental and clinical studies on S6472 (a new prolonged acting preparation of cefaclor) in the urological field].

Author: ArakawaS, FujiiA, HaradaM, HirookaK, IshigamiJ, KamidonoS, KataokaN, MatsushitaM, ShimataniN, UmezuK

Paper Details 
Original Abstract of the Article :
Fundamental and clinical studies on S6472, a new prolonged acting preparation of cefaclor, were performed and the following results were obtained. Serum level and urinary excretion. 750 mg of S6472, 500 mg of cefaclor (CCL) and 500 mg of cephalexin (CEX) were orally administered in 6 healthy adult v...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/3928939

データ提供:米国国立医学図書館(NLM)

Fundamental and Clinical Studies on S6472

This study examines the pharmacological properties and clinical efficacy of S6472, a new prolonged-acting preparation of cefaclor, in the treatment of urinary tract infections (UTIs). The authors conducted fundamental and clinical studies to assess the drug's serum levels, urinary excretion, and therapeutic effectiveness in various UTI scenarios.

Evaluating the Effectiveness of S6472 for UTIs

The study found that S6472 exhibited prolonged serum levels and urinary excretion compared to standard cefaclor and cephalexin. This suggests that S6472 could potentially offer more sustained therapeutic efficacy in treating UTIs. The clinical evaluation of S6472 demonstrated promising results, particularly in the treatment of uncomplicated cystitis. The effectiveness rate for uncomplicated cystitis was remarkably high, indicating that S6472 could be a valuable tool for treating this common condition.

Implications for UTI Treatment

The study's findings suggest that S6472 could be a viable treatment option for UTIs, particularly for uncomplicated cystitis. The prolonged action of S6472 could simplify treatment regimens and potentially improve patient compliance. However, it's important to note that the study also reported some adverse effects, such as diarrhea, epigastralgia, and stomatitis, which should be carefully considered in clinical practice. Just as a traveler in a desert must be mindful of potential hazards, healthcare providers need to be aware of potential side effects and ensure that patients are closely monitored during treatment.

Dr.Camel's Conclusion

The study offers valuable insights into the potential of S6472 as a new and effective treatment for UTIs. While the drug shows promise, further research is needed to fully understand its long-term efficacy and safety profile. As always, careful monitoring and patient-centered care are essential in managing UTIs and ensuring optimal treatment outcomes.

Date :
  1. Date Completed 1985-10-08
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

3928939

DOI: Digital Object Identifier

3928939

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PICO Info
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Languages

Japanese

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