Side Effects of cefaclor: A Synthesis of Findings from 27 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of cefaclor: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Cefaclor is an antibiotic used to prevent and treat bacterial infections. Several studies have shown cefaclor to be safe and effective. For instance, the study in 9 found that cefaclor effectively reduces the risk of recurrent urinary tract infections in children with vesicoureteral reflux. Additionally, the research in 8 showed cefaclor to be effective in treating uncomplicated acute urinary tract infections. Cefaclor is safe and easy to take, making it suitable for use in children and the elderly. However, the study in 4 revealed that cefaclor has a higher risk of hypersensitivity reactions, particularly anaphylaxis, compared to other cephalosporin antibiotics.

Reasons for Side Effects

Side effects of cefaclor occur when the drug is absorbed into the body and acts on various tissues and organs. Cefaclor works by inhibiting the synthesis of bacterial cell walls, thereby stopping bacterial growth. However, cefaclor can also affect human cells, potentially causing side effects.

Common Side Effects

Gastrointestinal

The most frequent side effect of cefaclor is gastrointestinal issues. Studies such as 8 , 14 , 15 , 11 , 2 , 26 , 19 , 17 , 16 , 1 , 18 , 19 , 4 have reported symptoms such as diarrhea, nausea, vomiting, and abdominal pain. These symptoms can occur when cefaclor alters the intestinal flora.

Allergies

Cefaclor can trigger allergic reactions. The research in 4 demonstrated that cefaclor has a higher risk of hypersensitivity reactions, especially anaphylaxis, compared to other cephalosporin antibiotics. Allergic reactions manifest as symptoms like rash, itching, and difficulty breathing. In severe cases, anaphylactic shock can occur, which can be life-threatening.

Blood

Cefaclor can impact blood cells. The study in 21 observed leukopenia and thrombocytosis in a subset of children who took cefaclor. These symptoms are generally mild and temporary.

Liver

Cefaclor can affect the liver. The study in 21 found elevated GOT (glutamic oxaloacetic transaminase) and GPT (glutamic pyruvate transaminase) levels in a portion of children who took cefaclor. These symptoms are typically mild and temporary.

Side Effect Countermeasures

Gastrointestinal

If you experience gastrointestinal symptoms, consult your doctor. Mild symptoms may be improved with dietary or drug therapy. In severe cases, you may need to stop taking cefaclor.

Allergies

If you have an allergic reaction to cefaclor, consult your doctor immediately. If you experience a severe reaction such as anaphylactic shock, emergency treatment is required.

Blood

If you notice any abnormalities in your blood cells while taking cefaclor, consult your doctor.

Liver

If you notice any abnormalities in your liver function while taking cefaclor, consult your doctor.

Comparison Between Studies

Common Points of Studies

Many studies have shown that cefaclor is an effective drug for preventing urinary tract infections and treating bacterial infections. It is also common that cefaclor is a relatively safe and easy-to-take drug.

Differences Between Studies

There may be differences in the results of studies on the side effects of cefaclor. For example, the study in 4 showed that cefaclor has a higher risk of hypersensitivity reactions, particularly anaphylaxis, compared to other cephalosporin antibiotics. On the other hand, other studies have shown that the risk of hypersensitivity reactions to cefaclor is no different from other cephalosporin antibiotics. Further research on the side effects of cefaclor is needed.

Precautions for Application in Daily Life

Take cefaclor as directed by your doctor. Cefaclor can interact with other medications, so consult your doctor if you are taking other medications. Cefaclor may not be suitable for pregnant or breastfeeding women, or people with kidney or liver disease. Consult your doctor and take it as instructed.

Limitations of Current Research

The side effects of cefaclor are not yet fully understood. In particular, the side effects of long-term use need further research.

Future Research Directions

Large-scale clinical trials are needed to better understand the side effects of cefaclor. Also, research on how to reduce the side effects of cefaclor is needed.

Conclusion

Cefaclor is an antibiotic used to prevent urinary tract infections and treat bacterial infections. Multiple studies have shown that cefaclor is a safe and effective drug. However, cefaclor can interact with other medications, and may not be suitable for pregnant or breastfeeding women, or people with kidney or liver disease. The side effects of cefaclor are not yet fully understood. Consult your doctor and take it as instructed.

Keywords
Benefit Keywords
Effective for bronchitis
Effective for pneumonia
Well tolerated
1
Treat urinary tract infections
2
Sinusitis treatment
3
Chronic respiratory infection treatment
5
Skin infection treatment
Soft tissue infection treatment
6
Effective antibiotic
Safe for children
7
Once-daily dosing
Treats UTIs
8
Recurrent UTI prevention
9
Lower respiratory tract infection treatment
10
Treat otitis media
11
Strep throat treatment
12
Pneumonia treatment
13
Chronic bronchitis treatment
14
UTI treatment
15
Bacterial infection treatment
Effective against various bacteria
Well tolerated
16
Effective against UTI
Treats cystitis
17
Effective otitis media treatment
18
Effective for pneumococcal pneumonia
19
Cefaclor for LRTI
Roxithromycin for LRTI
20
Antibacterial activity
Pediatric efficacy
21
Effective otorhinolaryngology treatment
22
Effective treatment
23
Effective maxillary sinusitis treatment
24
Antibacterial activity
Clinical efficacy
Safe for pediatric patients
25
Bacteriologically effective
Effective for skin infections
26
Otitis media treatment
27
Risk Keywords
Side effects
1
Diarrhea
Epigastralgia
Eruption
Facial swelling
Stomatitis
2
Anaphylaxis
Hypersensitivity
4
Ineffective for bronchiectasis
5
Elevated liver enzymes
Elevated platelets
7
Leucopenia
Nausea
Vomiting
Yeast infections
8
Resistance
9
Gastrointestinal side effects
10
Side effects
11
GI side effects
12
Diarrhea
Headache
Nausea
Respiratory disorders
13
Side effects
14
Minor side effects
15
None mentioned
16
Side effects
17
Side effects
18
Diarrhea
19
Cefaclor side effects
Roxithromycin side effects
20
Elevated eosinophils
Elevated liver enzymes
Increased platelet count
21
Mild side effects
Transient lab abnormalities
22
Nausea
23
Abnormal lab values
GI side effects
26
Gastrointestinal complaints
27
Literature analysis of 27 papers
Positive Content
26
Neutral Content
0
Negative Content
1
Article Type
12
0
0
0
27
1.

Multicenter evaluation of azithromycin and cefaclor in acute lower respiratory tract infections.

Author: DarkD

Effective for bronchitis
Effective for pneumonia
Well tolerated
Side effects

A 5-day course of once-daily azithromycin was as effective as a 10-day three times daily course of cefaclor in treating acute lower respiratory tract infections, with similar safety profiles.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

[Fundamental and clinical studies on S6472 (a new prolonged acting preparation of cefaclor) in the urological field].

Author: KamidonoS, FujiiA, HaradaM, ArakawaS, UmezuK, KataokaN, IshigamiJ, HirookaK, ShimataniN, MatsushitaM

Treat urinary tract infections
Diarrhea
Epigastralgia
Eruption
Facial swelling
Stomatitis

S6472, a prolonged acting preparation of cefaclor, is effective in treating urinary tract infections. Side effects are generally mild and transient.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

3.

[Acute sinusitis in adults].

Author: EkedahlC

Sinusitis treatment

Cefaclor and doxycycline were compared in a double-blind study of 213 patients with acute sinusitis. Both drugs achieved excellent results in 88% and 83% of patients, respectively. Cefaclor was associated with side-effects in 7% of patients, while doxycycline had side-effects in 13%. Cefaclor is recommended as an alternative to penicillin in cases of penicillin allergy or resistance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

4.

Cefaclor-induced hypersensitivity: Differences in the incidence of anaphylaxis relative to other 2nd and 3rd generation cephalosporins.

Author: RhyouHyo-In, NamYoung-Hee, KimSu-Chin, DooGo-Eun, HaChae-Yeon, NamHee-Joo, WooSung-Dae, LeeYoungsoo, JangJae-Hyuk, LeeHyun-Young, YeYoung-Min

Anaphylaxis
Hypersensitivity

Cefaclor is a commonly prescribed cephalosporin in Korea. This study found that cefaclor had a high incidence of adverse drug reactions (ADRs), particularly hypersensitivity (HS) and anaphylaxis. The incidence of ADRs, HS, and anaphylaxis was 1.92/10,000 persons, 1.17/10,000 persons, and 0.38/10,000 persons, respectively. HS was more common in women, individuals under 65 years old, and those who were using other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

[Clinical studies on S 6472 granule preparation (sustained-release cefaclor) in chronic respiratory tract infections].

Author: AonumaS, OizumiK, WatanabeA, TokueY, HondaY, OnoR, KitamuraN, KonnoK, SatohK

Chronic respiratory infection treatment
Ineffective for bronchiectasis

Sustained-release cefaclor was effective in 80% of patients with chronic respiratory tract infections. The drug was ineffective in 3 of 10 patients with bronchiectasis but effective in the other 12 patients.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

6.

A comparative study of the efficacy, safety and tolerability of azithromycin and cefaclor in the treatment of children with acute skin and/or soft tissue infections.

Author: MonteroL

Skin infection treatment
Soft tissue infection treatment

This study compared the efficacy and safety of azithromycin and cefaclor in treating skin and/or soft tissue infections in children. Both treatments were comparable in efficacy and well-tolerated, with a low incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Laboratory and clinical studies on cefprozil in the field of pediatrics].

Author: HayakawaF, KunoK, OgawaA, NakaoY, AndoY, AndoH

Effective antibiotic
Safe for children
Elevated liver enzymes
Elevated platelets

Cefprozil (CFPZ) demonstrated superior antibacterial activity against Gram-positive cocci compared to cefaclor and against E. coli compared to ampicillin. In pediatric patients with acute infections, CFPZ achieved a 100% clinical efficacy rate and 56% bacteriological efficacy rate with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

8.

Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections.

Author: ChristensonJ C, GoochW M, HerrodJ N, SwensonE

Once-daily dosing
Treats UTIs
Leucopenia
Nausea
Vomiting
Yeast infections

Cefprozil, a new oral cephalosporin, was found to be as effective as cefaclor in treating acute, uncomplicated urinary tract infections. In a study of 98 patients, clinical and bacteriological responses were comparable for both antibiotics. Leucopenia, nausea, and vaginal yeast infections were slightly more common in the cefprozil group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux.

Author: KanekoKazunari, OhtomoYoshiyuki, ShimizuToshiaki, YamashiroYuichiro, YamatakaAtsuyuki, MiyanoTakeshi

Recurrent UTI prevention
Resistance

This study investigated whether antibiotic prophylaxis using low-dose cefaclor can effectively reduce the risk of recurrent urinary tract infections (UTIs) in children with vesicoureteral reflux (VUR). Cefaclor was well accepted and tolerated by all subjects. None withdrew from the study because of side effects. These results suggest that cefaclor can be an alternative choice for prophylactic treatment because of its safety, good compliance and low rates of resistant Escherichia coli.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Randomized comparative study of ceftibuten versus cefaclor in the treatment of acute lower respiratory tract infections.

Author: KammerR B, RessR

Lower respiratory tract infection treatment
Gastrointestinal side effects

Ceftibuten was as effective as cefaclor in treating acute lower respiratory tract infections, with similar adverse experiences reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

[Clinical efficacy and tolerability of short course therapy with cefaclor compared with long-term therapy for treatment of acute otitis media in children].

Author: CataniaSalvatore, GalloAndrea

Treat otitis media
Side effects

This study compared the clinical efficacy and tolerability of two different cefaclor regimens in children with acute otitis media (AOM). Both regimens, 50 mg/kg/day for 5 days and 40 mg/kg/day for 10 days, showed high cure rates (95.5% and 94.8%, respectively) with similar recurrence rates and mild side effects. Short-course treatment appears preferable due to better compliance and tolerability.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

12.

Azithromycin versus cefaclor in the treatment of pediatric patients with acute group A beta-hemolytic streptococcal tonsillopharyngitis.

Author: CremerJ, WallrauchC, MilatovicD, BravenyI

Strep throat treatment
GI side effects

Azithromycin and cefaclor showed similar clinical success rates in treating group A beta-hemolytic streptococcal tonsillopharyngitis in children. However, bacterial eradication was lower with azithromycin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Cefaclor advanced formulation versus cefaclor in the treatment of pneumonia.

Author: CasaliL, VoiM, JanssenC J, OlovichK G, DereW H

Pneumonia treatment
Diarrhea
Headache
Nausea
Respiratory disorders

Cefaclor advanced formulation (cefaclor AF) was compared to cefaclor for the treatment of pneumonia in 266 patients. Both drugs showed similar efficacy against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

[Clinical evaluation of S 6472 granule preparation (sustained-release cefaclor) in chronic bronchitis].

Author: HiragaY, OmichiM, SasaokaS

Chronic bronchitis treatment
Side effects

Sustained-release cefaclor was effective in treating acutely exacerbated chronic bronchitis in 85% of patients. The drug was well-tolerated with no side effects or abnormal laboratory findings.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

15.

[Comparative studies of the efficacy, safety and usefulness of S6472, cefaclor and cephalexin on complicated urinary tract infection by the double-blind method].

Author: KamidonoS, ArakawaS, FujiiA, KataokaN, UmezuK, IshigamiJ, HirookaK, ShimataniN, MatsushitaM, HikosakaK

UTI treatment
Minor side effects

Cefaclor (standard and long-acting formulations) and cephalexin were all effective for uncomplicated urinary tract infection in 385 patients. All three had a low rate of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

16.

[Fundamental and clinical studies on cefixime (5% granules) in the pediatric field].

Author: ToyonagaY, SugitaM, NakamuraH, JohK, TakahashiT, KurosuY, HoriM

Bacterial infection treatment
Effective against various bacteria
Well tolerated
None mentioned

Cefixime (CFIX) 5% granules showed greater activity than other antibiotics against several Gram-negative bacteria. The study found that CFIX was effective in treating infections in 33 patients with a 97.0% effectiveness rate.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

17.

[Effect of cefaclor in urinary tract infections (2)].

Author: KajikawaH, HosokawaS, KameokaH, NishimotoN, MiyoshiS, IwaoN, MizutaniS

Effective against UTI
Treats cystitis
Side effects

Cefaclor (CCL), a daily dose of 0.75 g t.i.d., was effective in treating 98.7% of 76 cases of uncomplicated acute cystitis in women and 60% of 55 cases of complicated cystitis. Side effects were reported in 13 cases out of 150.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

18.

Comparative efficacies of erythromycin-sulfisoxazole and cefaclor in acute otitis media: a double blind randomized trial.

Author: BergeronM G, AhronheimG, RichardJ E, RidingK, CronC, BryerD, MacdonaldN, BouchardM, YoungJ, DempseyE E

Effective otitis media treatment
Side effects

Erythromycin-sulfisoxazole (E/S) was found to be as effective as cefaclor in treating 119 children with acute otitis media. E/S was associated with more rapid improvement in otoscopic findings and may be superior for patients with bacteriologically sterile middle ear fluid.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Cefadroxil compared with cefaclor in the treatment of streptococcal pneumonia in adults.

Author: ZeLuffB, CatchpoleM, LoweP, KoornhofH, GentryL

Effective for pneumococcal pneumonia
Diarrhea

Cefadroxil and cefaclor were effective in treating pneumococcal pneumonia in gold miners. Both antibiotics demonstrated high efficacy and good tolerance, suggesting their potential for treating respiratory tract infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

A randomized double-blind controlled trial of roxithromycin and cefaclor in the treatment of acute lower respiratory tract infections in general practice.

Author: TilyardM W, DoveyS M

Cefaclor for LRTI
Roxithromycin for LRTI
Cefaclor side effects
Roxithromycin side effects

Roxithromycin and cefaclor were equally effective in treating acute lower respiratory tract infections in 200 general practice patients, with a satisfactory or improved response in 95% of patients for both drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

[Bacteriological, pharmacokinetic and clinical studies on cefteram pivoxil in the pediatric field].

Author: ToyonagaY, ImaiH, SugitaM, FukushimaY, YamazakiM, HoriM

Antibacterial activity
Pediatric efficacy
Elevated eosinophils
Elevated liver enzymes
Increased platelet count

Cefteram pivoxil (CFTM-PI), a new oral cephalosporin, was effective in treating pediatric infections. The efficacy rate was 97.6%, and side effects were minimal.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

22.

[Clinical studies of S6472 in otorhinolaryngologic infections].

Author: BabaS, KinoshitaH, MoriY, SuzukiK, OhyamaM, KatsutaK, FurutaS, OhnoI, NoboruT, YamamotoM

Effective otorhinolaryngology treatment
Mild side effects
Transient lab abnormalities

S6472, a long-acting preparation of cefaclor, was effective in 65.8% of 114 patients with otorhinolaryngology infections, particularly tonsillitis, with mild side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

23.

Clinical comparison of cefaclor twice daily versus amoxicillin-clavulanate or erythromycin three times daily in the treatment of patients with streptococcal pharyngitis.

Author: EspositoS, De RitisG, D'ErricoG, NovielloS, IannielloF

Effective treatment
Nausea

Cefaclor 25 mg/kg BID was found to be as effective as amoxicillin-clavulanate 15 mg/kg TID and more effective than erythromycin 15 mg/kg TID for the treatment of pediatric patients with acute pharyngotonsillitis (APT).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

[Acute maxillary sinusitis treated with cefaclor].

Author: BüyükgebizA, KinikE

Effective maxillary sinusitis treatment

Cefaclor is effective in treating acute maxillary sinusitis in children with high cure rates and no side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Turkish

25.

[Basic and clinical studies on cefditoren pivoxil in pediatric field].

Author: MotohiroT, HandaS, YamadaS, OkiS, YoshinagaY, SasakiH, AramakiM, OdaK, SakataY, KatoH

Antibacterial activity
Clinical efficacy
Safe for pediatric patients

Cefditoren pivoxil, a new oral cephem, showed excellent antibacterial activity against clinical isolates, with MICs comparable to or lower than conventional cephems. The drug was clinically effective in 53 pediatric patients with various infections, with no observed side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

26.

[Clinical evaluation of cefpodoxime proxetil in the treatment of skin and soft tissue infections. A double blind comparison of cefpodoxime proxetil and cefaclor].

Author: YuraJ, ShinagawaN, MizunoA, WatanabeS, AndoM, SakaiK, UedaT, MorimotoK, NakamuraT, HashimotoI

Bacteriologically effective
Effective for skin infections
Abnormal lab values
GI side effects

Cefpodoxime proxetil (CPDX-PR) was as effective as cefaclor (CCL) in treating skin and soft tissue infections in 243 patients. Both drugs were well tolerated, with no significant differences in side effects or usefulness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

27.

Amoxicillin-clavulanate potassium compared with cefaclor for acute otitis media in infants and children.

Author: KaleidaP H, BluestoneC D, RocketteH E, BassL W, WolfsonJ H, BreckJ M, UbingerE B, RohnD D

Otitis media treatment
Gastrointestinal complaints

This study compared the effectiveness of amoxicillin-clavulanate potassium and cefaclor in treating ear infections in children. Both drugs were effective in clearing ear infections, but amoxicillin-clavulanate potassium caused more gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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