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Double-blind trial comparing labetalol with atenolol in the treatment of systemic hypertension with angina pectoris.

Author: JeeL D, OpieL H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 10 patients with high blood pressure and angina found that both labetalol and atenolol were equally effective in controlling blood pressure, improving exercise tolerance, and reducing the need for nitroglycerin. However, labetalol caused a significantly higher heart rate at rest and during exercise (p<0.01) compared to atenolol. Despite the higher heart rate, labetalol did not change the heart rate-blood pressure product during exercise, suggesting potential benefits for some patients. The study concludes that both medications have advantages: labetalol due to its potential for improved exercise tolerance and atenolol for its cardioselectivity, hydrophilicity, and once-daily dosing.
Paper Details　
Original Abstract of the Article :
Some theoretical arguments suggest that added vasodilation could be beneficial in the management of patients with systemic hypertension and angina pectoris. Ten patients were studied in a double-blind crossover trial in which the severity of hypertension and angina pectoris was monitored. The initia...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9149(85)91183-x

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1985-10-22
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

3929584

DOI: Digital Object Identifier

10.1016/0002-9149(85)91183-x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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