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Patterns of attrition for psychosocial and pharmacologic treatments of depression.

Author: BellackA S, HersenM, HimmelhochJ M, LastC G, ThaseM E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A study of 125 women with depression found that those who prematurely stopped pharmacotherapy tended to have milder depression and were sensitive to medication side effects. In contrast, those who dropped out of psychosocial therapy were more severely depressed and dissatisfied with the lack of immediate improvement. The study suggests that short-term psychosocial interventions may be preferable to medication for milder forms of non-endogenous depression. However, antidepressant medication, alone or in combination with therapy, remains the preferred option for more severe melancholic depression.
Paper Details　
Original Abstract of the Article :
Patient characteristics associated with early termination from psychosocial and pharmacologic treatments of depression were delineated. Patients were 125 female primary nonbipolar depressives randomly assigned to 12 weeks of protocol treatment in one of four conditions: social skills training plus p...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/4030699

データ提供：米国国立医学図書館（NLM）

Understanding Attrition in Depression Treatment

This research explores the characteristics of patients who prematurely terminate from psychosocial and pharmacologic treatments for depression. The study utilizes a randomized controlled trial design to compare four different treatment conditions: social skills training plus placebo, short-term psychotherapy plus placebo, amitriptyline alone, and social skills training plus amitriptyline.

Patient Characteristics Influence Treatment Attrition

The study found that patients who discontinued pharmacotherapy tended to be mildly depressed and experience medication side effects. In contrast, patients who dropped out of psychosocial treatment were more severely depressed and dissatisfied with the lack of early response. These findings suggest that patient characteristics and treatment expectations can significantly impact attrition rates.

Tailoring Treatment Approaches for Optimal Outcomes

The study emphasizes the importance of considering patient characteristics when selecting treatment approaches for depression. Short-term psychosocial interventions may be suitable for patients with mild depression, while pharmacotherapy or combined approaches may be more effective for those with more severe symptoms. Personalized treatment plans can help improve patient engagement and maximize treatment outcomes.

Dr. Camel's Conclusion

This study reminds us that the path to recovery from depression is not always straightforward. Dr. Camel notes that just as the camel must navigate a challenging desert environment, individuals with depression may face obstacles in their treatment journey. The study underscores the importance of understanding patient characteristics and tailoring treatment strategies to optimize outcomes.

Date :
  1. Date Completed 1985-10-09
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

4030699

DOI: Digital Object Identifier

4030699

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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