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Comparative treatment trial of augmentin versus cefaclor for acute otitis media with effusion.

Author: KusmieszH, NelsonJ D, OdioC M, SheltonS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amoxicillin-clavulanate was better than cefaclor for treating acute otitis media in children (no treatment failures vs. 8%), but it caused more side effects (diarrhea and rash).
Paper Details　
Original Abstract of the Article :
A total of 150 children with acute otitis media were randomly allocated to treatment with amoxicillin-potassium clavulanate (Augmentin) or with cefaclor. Each drug was given in a daily dosage of approximately 40 mg/kg in three divided doses for ten days. Tympanocentesis done before treatment yielded...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/4039433

データ提供：米国国立医学図書館（NLM）

Augmentin vs. Cefaclor: A Duel in the Otitis Media Arena

The [Otitis media] battlefield is filled with tiny warriors, [bacteria] fighting for dominance in the delicate ecosystem of the ear. This study pits two antibiotic combatants, [Augmentin] and [Cefaclor], against each other to determine which one reigns supreme in treating [Acute otitis media with effusion].

Augmentin Emerges as the Victor

The study concluded that [Augmentin] was superior to [Cefaclor] in treating the acute phase of [Acute otitis media with effusion]. While both treatments showed comparable effectiveness in terms of long-term outcomes, [Augmentin] demonstrated a clear advantage in the initial battle against the invading [bacteria].

Side Effects: A Balancing Act

However, the study also revealed that [Augmentin] had a higher rate of side effects, such as [diarrhea] and [diapers rash], compared to [Cefaclor]. This finding highlights the importance of considering both effectiveness and potential side effects when choosing a treatment option for [Acute otitis media with effusion].

Dr.Camel's Conclusion

The battle for [Otitis media] continues, with [Augmentin] demonstrating its prowess in the initial stages. However, the potential side effects warrant careful consideration. Further research is needed to find the perfect balance between effectiveness and safety in the ongoing fight against this common ailment.

Date :
  1. Date Completed 1985-06-18
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

4039433

DOI: Digital Object Identifier

4039433

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Languages

English

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