Paper Details

  1. Home
  2. Paper Details

Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism.

Author: DugganD E, HookeK F, LinJ H, YehK C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Saturable metabolism and protein binding were found to affect the pharmacokinetics of diflunisal in rats. Both processes contributed to a decrease in total body plasma clearance at higher concentrations.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to define the dual effects of saturable metabolism and saturable protein binding on the pharmacokinetics of diflunisal. Steady-state diflunisal concentration and its unbound fraction were examined in seven groups of rats to determine the relationships of infusion rate, ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/4057077

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1985-12-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

4057077

DOI: Digital Object Identifier

4057077

Related Literature

Article Analysis
・Effects of diflunisal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.