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Azathioprine in ulcerative colitis: final report on controlled therapeutic trial.

Author: JewellD P, TrueloveS C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 80 patients with ulcerative colitis found that adding azathioprine to standard corticosteroid treatment did not improve outcomes during an acute attack. While azathioprine did not benefit patients experiencing their first attack, it showed potential benefit in preventing relapses in patients with established disease. However, this difference did not reach statistical significance. The study suggests that azathioprine may have a role in managing ulcerative colitis, particularly for those with recurring disease, but further research is needed to confirm its effectiveness.
Paper Details　
Original Abstract of the Article :
Eighty patients, all of whom were suffering from a frank clinical attack of ulcerative colitis, were admitted to the trial. The attack was treated with a standard course of corticosteroids and the patients were immediately placed on treatment with either azathioprine in a dose of 2.5 mg/kg body weig...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.4.5945.627

データ提供：米国国立医学図書館（NLM）

Azathioprine and Ulcerative Colitis: A Quest for Stability in the Desert of Inflammatory Bowel Disease

This research delves into the complex world of [inflammatory bowel disease] (IBD), exploring the potential role of [azathioprine] in managing [ulcerative colitis]. The study, a [controlled therapeutic trial], investigated the efficacy of [azathioprine] in [80 patients] with [ulcerative colitis]. The authors discovered that while [azathioprine] did not offer significant benefit in the treatment of [acute attacks] of [ulcerative colitis], it showed some promise in [maintaining remission] in patients with [established disease]. This finding suggests that [azathioprine] could be a valuable tool in managing the long-term course of [ulcerative colitis], potentially preventing relapses and improving quality of life for individuals living with this chronic condition.

A Glimpse of Hope in the Desert: Azathioprine's Potential for Remission

This research provides valuable insights into the potential therapeutic benefits of [azathioprine] for individuals struggling with [ulcerative colitis]. While further investigation is needed to fully understand its role, the study's findings offer a glimmer of hope for patients seeking a more stable and manageable course of their disease. The results encourage continued research into the use of [azathioprine] and other immunomodulatory therapies for [ulcerative colitis], aiming to provide long-term relief and improved quality of life for those affected.

Navigating the Sands of IBD: A Journey of Personalized Management

This research highlights the importance of a personalized approach to [IBD] management. The study emphasizes the need for individualized treatment plans tailored to the specific needs and characteristics of each patient. It underscores the value of continued research and innovation in developing effective and safe therapies for individuals living with this complex and challenging condition.

Dr. Camel's Conclusion

The journey through the desert of IBD can be arduous, but this research provides a glimmer of hope for those seeking a more stable and manageable course. The study's findings suggest that azathioprine may play a role in maintaining remission, offering a potential oasis of stability for patients with established disease. By embracing a personalized approach and continuing to explore new therapeutic options, we can chart a course toward a brighter future for those living with IBD.

Date :
  1. Date Completed 1975-04-19
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

4441827

DOI: Digital Object Identifier

10.1136/bmj.4.5945.627

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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