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Methylphenidate and d-amphetamine: effects and interactions with alphamethyltyrosine and tetrabenazine on DRL performance in rats.
Author: AndresenJ, MacPhailR C, SeidenL S
Original Abstract of the Article :
The effects of d-amphetamine and methylphenidate and their interactions with amine-depleting drugs were examined in rats trained to press a lever to obtain water reinforcement on a schedule that differentially reinforced responding at low rates (DRL). Both methylphenidate (2.5-20.0 mg/kg) and d-amph...See full text at original site
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引用元：
https://doi.org/10.1016/0091-3057(79)90236-3
データ提供：米国国立医学図書館（NLM）
Methylphenidate and d-Amphetamine: Exploring the Brain's Desert
The field of Neuropharmacology is an expansive desert, where researchers delve into the intricate workings of the brain and the effects of various drugs on its functions. This study, published in the field of Pharmacology, investigates the effects of methylphenidate and d-amphetamine, commonly used stimulants, on the performance of rats on a differential reinforcement of low rates (DRL) schedule. The researchers explored the effects of these stimulants on response rate, reinforcement frequency, and interresponse time (IRT) distributions, and investigated how these effects were influenced by the administration of amine-depleting drugs, alphamethyltyrosine (AMT) and tetrabenazine (TBZ).
Methylphenidate and d-Amphetamine: Exploring the Brain's Desert
The study's findings suggest that methylphenidate and d-amphetamine, both stimulants, exert similar effects on DRL performance in rats, increasing response rate and decreasing reinforcement frequency. The researchers found that both drugs shifted the IRT distributions to the left, suggesting that they influenced the timing and frequency of responses. These findings provide insights into the mechanisms by which these stimulants act on the brain, influencing behavior and performance.
Navigating the Desert of Neuropharmacology: Understanding Drug Effects
This study offers a glimpse into the complex and often unpredictable world of neuropharmacology. The researchers' findings highlight the need for careful consideration of the effects of stimulants on brain function and behavior, emphasizing the importance of tailoring treatment strategies to individual needs and potential side effects.
Dr. Camel's Conclusion
This study, like a journey through the vast desert of neuropharmacology, reveals the complex interplay between stimulants, brain function, and behavior. The researchers' findings highlight the need for a nuanced understanding of the effects of these drugs and the importance of carefully considering individual differences when utilizing them for therapeutic purposes.
Date :
- Date Completed 1979-09-17
- Date Revised 2019-07-12
Further Info :
Related Literature
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