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Loperamide in patients with radiotherapy-induced diarrhoea.

Author: ChapauxJ, ChapauxP, RoyerE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Loperamide (Imodium) was effective in reducing the frequency and consistency of stools in 63 patients with irradiation-induced diarrhea. Stools became normal in 41 patients after a median time of 16.5 days. No side effects were attributed to the drug.
Paper Details　
Original Abstract of the Article :
63 patients (23--78 years) with irradiation-induced diarrhoea, the majority of them resistant to treatment with diphenoxylate, were started on 4-(p-chlorophenyl)-4-hydroxy-N,N'-dimethyl-alpha,alpha-diphenyl-1-piperidine butyramide (loperidine, Imodium) 4 mg daily. Doses were further adapted individu...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/581966

データ提供：米国国立医学図書館（NLM）

Loperamide: A Potential Solution for Radiotherapy-Induced Diarrhoea

Radiotherapy, a powerful tool in cancer treatment, can sometimes have debilitating side effects, including diarrhoea. This study investigates the effectiveness of loperamide, an anti-diarrheal medication, in managing radiotherapy-induced diarrhoea. Researchers analyzed the outcomes of loperamide treatment in patients experiencing diarrhoea resistant to other medications. The findings provide insights into the potential benefits of loperamide in alleviating this common side effect of radiotherapy.

Loperamide: A Potential Relief for Radiotherapy-Induced Diarrhoea

The study revealed that loperamide was effective in significantly improving stool frequency and consistency in a majority of patients experiencing radiotherapy-induced diarrhoea. The medication also effectively reduced abdominal cramps, offering a welcome relief from this distressing side effect. These findings suggest that loperamide could play a valuable role in enhancing the quality of life for patients undergoing radiotherapy.

Health Implications and Daily Considerations

This study highlights the importance of managing side effects during cancer treatment. Radiotherapy-induced diarrhoea can be a significant concern for patients, impacting their comfort and overall well-being. Discussions with your oncologist about potential side effects and available treatments are crucial to ensure that you receive the best possible care and support during your treatment journey.

Dr.Camel's Conclusion

Just as a camel navigates the desert, seeking out oases of relief, individuals undergoing radiotherapy may encounter the challenges of diarrhoea. This study reveals loperamide's potential to provide a much-needed oasis, offering relief from this debilitating side effect and improving the overall well-being of patients. By working closely with your healthcare providers, you can navigate the complexities of cancer treatment with greater comfort and confidence, reaching your destination with strength and resilience.

Date :
  1. Date Completed 1979-06-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

581966

DOI: Digital Object Identifier

581966

Related Literature

Article Analysis
・Side Effects of diphenoxylate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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