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Interactions of neuroleptic metabolites with dopaminergic, alpha adrenergic and muscarinic cholinergic receptors.

Author: BylundD B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Metabolite potency at dopaminergic, alpha adrenergic, and muscarinic cholinergic receptors correlated with clinical data on drug potency and side effects. The findings suggest that metabolites contribute significantly to both therapeutic and side effects of neuroleptics.
Paper Details　
Original Abstract of the Article :
Using the radioligand binding assay, the in vitro potency of three neuroleptic drugs at dopaminergic ([3H]spiroperidol), alpha adrenergic ([3H]WB-4101) and muscarinic cholinergic ([3H]quinuclidinyl benzilate) receptor binding sites was compared to the potency of 12 metabolites of these drugs at the ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6110776

データ提供：米国国立医学図書館（NLM）

Unmasking the Mystery: Neuroleptic Metabolites and Their Impact on the Brain

[Neurology] is a fascinating field, full of intricate pathways and delicate balances. This research investigates the complex interplay between neuroleptic drugs and their metabolites, exploring their impact on dopamine, alpha adrenergic, and muscarinic cholinergic receptors in the brain. This research sheds light on how these metabolites can influence both the therapeutic effects and side effects of neuroleptic medications.

The Hidden Hand: Metabolites and Their Influence on Receptors

The study found that metabolites of certain neuroleptic drugs can bind to various receptors in the brain, mimicking the effects of the parent drug. This explains why patients often experience both therapeutic and side effects associated with these medications. Interestingly, some metabolites were found to be more potent than the original drug at certain receptors, highlighting the importance of considering the impact of metabolites in drug development and treatment strategies.

Navigating the Brain's Complex Landscape

Think of the brain as a vast desert with intricate oases representing different receptors. Neuroleptic drugs are like travelers seeking to quench their thirst at specific oases. However, the researchers have discovered that these travelers are often accompanied by hidden companions, the metabolites, who also have a profound influence on the brain's landscape. This research underscores the complexity of drug action in the brain and the importance of studying not just the parent drug, but also its metabolic byproducts.

Dr. Camel's Conclusion

The study highlights the importance of considering metabolites when evaluating the effects of neuroleptic drugs. Understanding the interactions of these metabolites with receptors in the brain is crucial for optimizing treatment strategies and minimizing potential side effects. This research adds another layer of complexity to the study of neuroleptic drugs, but it also provides valuable insight into how these medications work within the intricate ecosystem of the brain.

Date :
  1. Date Completed 1981-05-26
  2. Date Revised 2017-11-17
Further Info :

Pubmed ID

6110776

DOI: Digital Object Identifier

6110776

SNS
PICO Info
in preparation
Languages

English

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