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Sulphasalazine retention enemas in ulcerative colitis: a double-blind trial.

Author: GoepelJ R, HoldsworthC D, PalmerK R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 34 patients with ulcerative colitis compared the effectiveness of sulphasalazine enemas to placebo. Sulphasalazine enemas significantly improved symptoms in patients who were not already taking oral sulphasalazine. Eleven out of 16 patients receiving sulphasalazine enemas improved compared to only 2 out of 18 receiving placebo. The treatment was well-tolerated, with no side effects observed, even in patients who previously experienced side effects from oral sulphasalazine. The study suggests that sulphasalazine enemas may be a good treatment option for patients who cannot tolerate oral sulphasalazine.
Paper Details　
Original Abstract of the Article :
Thirty-four patients with ulcerative colitis completed a double-blind assessment comparing the efficacy of two weeks of treatment with nightly retention enemas containing 3 g sulphasalazine or placebo. Symptom grading, sigmoidoscopic appearance, rectal biopsy specimens, and diary records were used t...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.282.6276.1571

データ提供：米国国立医学図書館（NLM）

Sulphasalazine Retention Enemas for Ulcerative Colitis: A Double-Blind Trial

Ulcerative colitis, a chronic inflammatory bowel disease, often requires tailored treatments to manage symptoms and improve quality of life. This research investigates the effectiveness of sulphasalazine retention enemas in patients with ulcerative colitis. The study, using a double-blind design, compared the effects of sulphasalazine enemas with a placebo. The findings suggest that sulphasalazine enemas can be effective in managing symptoms, particularly in patients who experience side effects from oral medications. The study highlights the importance of individualized treatment approaches to optimize outcomes in ulcerative colitis.

Finding Relief from Ulcerative Colitis: A Tailored Approach

This research demonstrates the importance of considering individual patient needs and preferences when developing treatment plans for ulcerative colitis. The study's findings suggest that sulphasalazine retention enemas can offer a valuable alternative for patients who experience side effects from oral medications. The study emphasizes the need for a flexible and individualized approach to managing ulcerative colitis to optimize treatment outcomes.

Navigating the Challenges of Inflammatory Bowel Disease

Living with ulcerative colitis often involves navigating the challenges of managing symptoms, finding effective treatments, and adjusting to lifestyle changes. This research underscores the importance of continued research to develop innovative treatments and better understand the complexities of inflammatory bowel diseases. It's a reminder that patients with ulcerative colitis benefit from a collaborative approach involving healthcare providers, researchers, and support groups to ensure optimal care and well-being.

Dr. Camel's Conclusion

Just as a camel adapts to the arid desert by storing water, individuals with ulcerative colitis need tailored treatment approaches to manage their condition. This research highlights the potential of sulphasalazine enemas as a valuable alternative for patients who experience side effects from oral medications. It's a reminder that the journey towards better health for individuals with inflammatory bowel disease is a collaborative effort, requiring a team of healthcare providers and ongoing research to uncover new and effective treatments.
Date :
  1. Date Completed 1981-08-10
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

6113021

DOI: Digital Object Identifier

10.1136/bmj.282.6276.1571

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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