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A comparison of the effects of neuroleptics on phencyclidine-induced behaviors in the rat.

Author: FesslerR G, LondonS F, MeltzerH Y, SturgeonR D

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Butyrophenone neuroleptics demonstrated dose-dependent antagonism of phencyclidine-induced behavioral effects in rats, while other neuroleptics had no consistent effect or even enhanced some effects. Atropine sulfate pretreatment increased PCP-induced locomotor activity and stereotyped behaviors, while physostigmine had the opposite effect.
Paper Details　
Original Abstract of the Article :
The dose-response effects of neuroleptic pretreatment on phencyclidine (PCP; 3 or 5 mg/kg)-induced locomotor activity, stereotyped behaviors and ataxia were quantified in groups of male rats using rating scales recently developed in this laboratory. Three butyrophenone neuroleptics consistently prod...See full text at original site
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引用元：
https://doi.org/10.1016/0014-2999(81)90007-8

データ提供：米国国立医学図書館（NLM）

Neuroleptics and Phencyclidine: A Complex Interaction

The study of neuroleptics, a class of drugs used to treat psychiatric conditions, is an ongoing journey of discovery. This research delves into the complex interaction between neuroleptics and phencyclidine (PCP), a drug known for its dissociative effects. The authors investigated the effects of various neuroleptics on PCP-induced behaviors in rats. They observed that different neuroleptics had varying effects on PCP-induced behaviors, with some antagonizing the effects while others enhancing them. The study also explored the potential role of dopaminergic and non-dopaminergic mechanisms in these interactions. Imagine a camel crossing a desert, its journey is influenced by various factors, like the terrain, weather, and its own internal compass. Similarly, understanding the interaction between neuroleptics and PCP requires considering a multitude of factors.

Neuroleptics: A Complex Landscape of Effects

This research reveals the complexity of neuroleptic action and their interactions with other drugs. The findings emphasize the importance of considering the specific neuroleptic and the potential for varying effects on PCP-induced behaviors.

Neuroleptics and PCP: A Journey of Understanding

This research provides valuable insights into the complex interaction between neuroleptics and PCP. The findings highlight the need for a deeper understanding of the underlying mechanisms involved, particularly the role of dopaminergic and non-dopaminergic systems. This knowledge could contribute to safer and more effective treatment strategies for individuals with psychiatric conditions.

Dr. Camel's Conclusion

This study sheds light on the intricate dance between neuroleptics and PCP. The findings emphasize the complexity of these interactions and the need for careful consideration when prescribing neuroleptics, especially in individuals who may be exposed to PCP. Continued research in this area is crucial for optimizing patient care and ensuring their safety.

Date :
  1. Date Completed 1982-03-13
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

6119221

DOI: Digital Object Identifier

10.1016/0014-2999(81)90007-8

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English

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