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Drug interactions in controlled clinical trials.

Author: GershonS

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Buspirone, diazepam, clorazepate, and placebo were evaluated for side effects with and without concomitant medications. Diazepam was associated with a higher incidence of side effects, but the increased sedation was not due to concomitant medications.
Paper Details　
Original Abstract of the Article :
As much information as possible should be obtained in clinical trials to assess possible interactions between test drugs and concomitant medications prescribed for other medical indications. Side effect profiles were compared in patients taking buspirone, mean = 20 mg/day; diazepam, 20 mg/day; clora...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6130080

データ提供：米国国立医学図書館（NLM）

Drug Interactions in Clinical Trials: Unveiling the Desert of Concomitant Medications

The study of drug interactions, like exploring a vast desert, requires careful observation and analysis. This research explores the potential interactions between test drugs and concomitant medications prescribed for other medical conditions. The researchers investigated the impact of various commonly used medications on the side effect profiles of buspirone, diazepam, clorazepate, and a placebo, in a large group of anxious patients.

Concomitant Medications Can Influence Side Effect Profiles

The research indicates that the use of concomitant medications can influence the side effect profiles of certain drugs. The study found that the use of various common medications did not significantly affect the side effect profiles of buspirone, clorazepate, or the placebo. However, the study did observe an increased incidence of side effects in the diazepam group when concomitant medications were used.

Implications for Clinical Trials and Patient Care

This research highlights the importance of carefully considering the impact of concomitant medications in clinical trials and patient care. The study's findings underscore the need for thorough investigation and documentation of any potential interactions between test drugs and other medications used by patients. This research encourages a comprehensive approach to medication management, considering the potential influence of co-administered drugs on treatment outcomes.

Dr. Camel's Conclusion

This research underscores the importance of navigating the desert of drug interactions with caution. Concomitant medications, like hidden sand dunes in a vast desert, can influence the effectiveness and side effect profiles of medications. This research encourages a comprehensive approach to medication management, considering the potential influence of other drugs on treatment outcomes.

Date :
  1. Date Completed 1983-03-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6130080

DOI: Digital Object Identifier

6130080

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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