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Respiratory depressant effects of different doses of midazolam and lack of reversal with naloxone--a double-blind randomized study.

Author: BachmannM, ForsterA, GemperleM, MorelD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Midazolam decreased tidal volume and increased respiratory frequency, but did not significantly affect minute ventilation. Naloxone did not reverse these effects.
Paper Details　
Original Abstract of the Article :
Conflicting data concerning the ventilatory effects of benzodiazepines may be caused by the large variability in investigational conditions. Respiratory effects of three different intravenous doses of midazolam (0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg) and placebo were measured in a double-blind and random...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6137171

データ提供：米国国立医学図書館（NLM）

Midazolam's Respiratory Effects: A Double-Blind Study

This study investigates the respiratory depressant effects of midazolam, a commonly used sedative and hypnotic drug. The researchers conducted a double-blind randomized study to measure the effects of different doses of midazolam on respiratory variables in healthy volunteers. They found that all doses of midazolam led to a decrease in tidal volume and an increase in respiratory frequency, while minute ventilation remained relatively unchanged. The study also found that naloxone, a drug used to reverse opioid overdose, did not reverse the respiratory effects of midazolam. These findings provide important insights into the respiratory effects of midazolam and highlight the need for careful monitoring during its administration.

Understanding the Respiratory Effects of Midazolam

The study's findings emphasize the importance of carefully managing the use of midazolam, particularly in individuals with respiratory compromise or those receiving other medications that can depress breathing. The lack of reversal by naloxone further underscores the unique respiratory effects of this drug.

Navigating the Sandstorm of Sedation

Imagine a desert where the winds of sedation can blow strong, potentially causing respiratory distress. This study explores the effects of midazolam, a common sedative, on breathing. The findings suggest that midazolam can have a complex impact on respiration, and it's important to be aware of these effects when using this medication.

Dr.Camel's Conclusion

This research highlights the importance of understanding the respiratory effects of medications like midazolam. The study's findings provide valuable information for healthcare professionals to consider when prescribing and monitoring this drug, particularly in individuals with pre-existing respiratory conditions. The lack of reversal by naloxone underscores the unique nature of midazolam's respiratory effects.

Date :
  1. Date Completed 1983-10-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6137171

DOI: Digital Object Identifier

6137171

SNS
PICO Info
in preparation
Languages

English

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