Paper Details

  1. Home
  2. Paper Details

Randomised trial of chemo-endocrine therapy, endocrine therapy, and mastectomy alone in postmenopausal patients with operable breast cancer and axillary node metastasis.

Author:

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 463 postmenopausal women with breast cancer compared three adjuvant treatments following mastectomy and lymph node removal: chemo-endocrine therapy (CMFp+T), endocrine therapy (p+T), and no treatment. Chemo-endocrine therapy significantly improved disease-free survival compared to both endocrine therapy and no treatment, and endocrine therapy also showed improved disease-free survival compared to no treatment. While there was no difference in overall survival between groups, chemo-endocrine therapy reduced all types of relapse (local, regional, and distant), while endocrine therapy only reduced local and regional relapses. These findings suggest that chemo-endocrine therapy offers the greatest benefit in preventing recurrence after breast cancer surgery.
Paper Details　
Original Abstract of the Article :
Adjuvant therapy after total mastectomy and axillary clearance in postmenopausal women with breast cancer and axillary node metastasis was assessed; chemo-endocrine therapy (cyclophosphamide, methotrexate, fluorouracil, prednisone, and tamoxifen; CMFp + T) was compared with endocrine therapy (predni...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/6144974

データ提供：米国国立医学図書館（NLM）

A Comprehensive Look at Breast Cancer Treatment in Postmenopausal Women

This research dives deep into the world of breast cancer treatment in postmenopausal women, a topic as vast as the Sahara Desert itself. The study uses a randomized trial to investigate the effectiveness of different adjuvant therapies, including chemo-endocrine therapy, endocrine therapy, and mastectomy alone, in patients with operable breast cancer and axillary node metastasis. The researchers meticulously compared these approaches to determine which treatment yielded the best results in terms of disease-free survival and overall survival.

Chemo-endocrine Therapy Shows Promise

The study revealed that chemo-endocrine therapy, a potent combination of medications, significantly improved disease-free survival compared to either endocrine therapy or no adjuvant treatment. This finding suggests that chemo-endocrine therapy may be a valuable tool in the fight against breast cancer. The study also found that endocrine therapy, while not as powerful as chemo-endocrine therapy, still showed a positive impact on disease-free survival.

Understanding the Implications for Patient Care

The researchers observed that chemo-endocrine therapy effectively reduced local, regional, and distant relapses, indicating a more comprehensive approach to battling the disease. Endocrine therapy, on the other hand, primarily reduced local and regional recurrences, suggesting a more targeted effect. These findings provide crucial insights into the potential benefits and drawbacks of each therapy and their impact on the progression of breast cancer.

Dr.Camel's Conclusion

This comprehensive study provides valuable insight into the efficacy of different treatment strategies for postmenopausal women with breast cancer. The results highlight the importance of carefully considering the specific needs of each patient when determining the most effective course of treatment. The study's findings offer a roadmap for future research and personalized medicine approaches in breast cancer care.
Date :
  1. Date Completed 1984-07-16
  2. Date Revised 2015-06-16
Further Info :

Pubmed ID

6144974

DOI: Digital Object Identifier

S0140-6736(84)92445-0

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.