Paper Details

  1. Home
  2. Paper Details

Treatment of disseminated breast cancer with tamoxifen, aminoglutethimide, hydrocortisone, and danazol, used in combination or sequentially.

Author: AshleyS, CoombesR C, FordH T, GazetJ C, NashA G, NevilleA M, PowlesT J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 222 patients with metastatic breast cancer compared a combination of hormone therapies (TAD) to tamoxifen alone. The combination therapy resulted in a significantly higher response rate (43% vs. 31%). While the duration of response was similar for both groups, patients receiving TAD achieved remission faster. Overall, patients in the TAD group had a longer cumulative time in endocrine remission (303 months vs. 264 months). However, there was no difference in survival between the two groups. These findings suggest that the combination therapy may be a more effective initial treatment for metastatic breast cancer, potentially leading to faster remission and longer time in remission.
Paper Details　
Original Abstract of the Article :
222 patients with disseminated breast cancer have been randomised to receive either a combination of hormone therapies using tamoxifen, aminoglutethimide with hydrocortisone, and danazol (TAD), or tamoxifen alone. The response to the combination was significantly better (43%) than that to tamoxifen ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0140-6736(84)91872-5

データ提供：米国国立医学図書館（NLM）

Disseminated Breast Cancer: Hormone Therapy Combinations

The treatment of disseminated breast cancer, a challenging condition, is a constant pursuit in oncology. This study investigates the effectiveness of a combination of hormone therapies (tamoxifen, aminoglutethimide with hydrocortisone, and danazol) compared to tamoxifen alone. The researchers evaluated the response rate, duration of response, and overall survival in 222 patients with disseminated breast cancer.

Combination Therapy: A Powerful Tool

The combination therapy (TAD) showed a significantly better response rate (43%) than tamoxifen alone (31%). The TAD patients also achieved remission more quickly, although the duration of response was similar. It is important to note that the overall survival was the same for both groups.

Hormonal Harmony: A Balancing Act

This study highlights the potential benefits of hormone therapy combinations in the treatment of disseminated breast cancer. However, it is essential to carefully consider the individual patient’s needs and potential side effects. As with any medical treatment, a personalized approach is key.

Dr. Camel's Conclusion

Like a careful blend of spices in a desert caravan's meal, the combination of hormones in this study offered improved outcomes for patients. The study underscores the importance of tailored therapy in cancer treatment, ensuring the right blend for each individual's needs.

Date :
  1. Date Completed 1984-07-30
  2. Date Revised 2019-06-11
Further Info :

Pubmed ID

6145832

DOI: Digital Object Identifier

10.1016/s0140-6736(84)91872-5

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.