Paper Details

  1. Home
  2. Paper Details

Comparison of effects of high and low dosage regimens of antithyroid drugs in the management of Graves' hyperthyroidism.

Author: BrombergN, FarahC S, ReisL C, RodriguesH F, RomaldiniJ H, TanakaL M, WernerM C, WernerR S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 113 patients with Graves' hyperthyroidism compared high doses of antithyroid drugs (methimazole or propylthiouracil) to lower doses. Patients receiving high doses had a significantly higher remission rate (75.4%) compared to those receiving lower doses (41.6%). The study also found that patients in remission had lower free T4 levels and a higher likelihood of decreasing antithyroid antibodies, suggesting a potential immunosuppressive effect of high-dose treatment. While high-dose treatment was associated with a higher remission rate, further research is needed to determine the long-term effectiveness and potential risks of this approach.
Paper Details　
Original Abstract of the Article :
We compared the effects of high and low dosages of antithyroid drugs in 113 patients with Graves' hyperthyroidism. The patients were randomly divided into 2 groups. In group A, 65 patients received either methimazole (MMI): 60 +/- 14.5 mg/day (mean +/- SD); range 40-100 mg/day, or propylthiouracil (...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1210/jcem-57-3-563

データ提供：米国国立医学図書館（NLM）

High Dose or Low Dose: A Comparison of Antithyroid Drug Regimens

This research compares the effects of [high-dose] and [low-dose] regimens of [antithyroid drugs] in the treatment of [Graves' hyperthyroidism]. The researchers, seeking to optimize treatment outcomes, conducted a randomized trial to assess the effectiveness of different dosing strategies. This research is a valuable contribution to our understanding of [Graves' hyperthyroidism] and its management.

The High Dose Advantage: Remission Rates and Thyroid Hormone Levels

The researchers found that patients treated with [high doses of antithyroid drugs] had a significantly higher [remission rate] compared to those treated with [lower doses]. This finding suggests that [high-dose therapy] may have a greater [immunosuppressive effect], leading to longer-lasting [remission]. The researchers also observed a correlation between [thyroid hormone levels] and [remission], with lower hormone levels associated with higher remission rates. This research highlights the importance of achieving [thyroid hormone suppression] in managing [Graves' hyperthyroidism] and achieving remission.

A New Perspective on Antithyroid Therapy: Optimizing Treatment for Graves' Hyperthyroidism

This research provides a new perspective on the [optimal treatment] for [Graves' hyperthyroidism], suggesting that [high-dose therapy] may offer a greater chance of [remission]. The researchers' findings challenge the conventional approach to [antithyroid drug] therapy, suggesting that a more aggressive approach may be more effective in achieving long-term remission. This research encourages a reevaluation of current [antithyroid drug] dosing strategies and a focus on individualized care to optimize patient outcomes.

Dr.Camel's Conclusion

This research delves into the desert of Graves' hyperthyroidism treatment, comparing the effectiveness of high-dose and low-dose antithyroid drug regimens. The study suggests that high-dose therapy may lead to a higher remission rate and emphasizes the importance of thyroid hormone suppression in managing this condition. It's a reminder that the quest for optimal treatment strategies is a continuous journey, and we must constantly seek new insights to improve patient care. This research encourages a more nuanced approach to antithyroid therapy, considering the unique needs of each patient and striving for the best possible outcomes.

Date :
  1. Date Completed 1983-09-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6192139

DOI: Digital Object Identifier

10.1210/jcem-57-3-563

Related Literature

Article Analysis
・Effective treatment of hyperthyroidism
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.