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Effects of the alpha-D-anomer of 5-aza-2'-deoxycytidine on L1210 mouse leukemic cells in vitro and in vivo.

Author: PískalaA, VeselýJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The alpha-D-anomer of 5-aza-2'-deoxycytidine inhibited cell growth in vitro and increased lifespan in mice with leukemia. It was less toxic than 5-aza-2'-deoxycytidine and inhibited 2'-deoxycytidine uptake and phosphorylation.
Paper Details　
Original Abstract of the Article :
The alpha-D-anomer of 5-aza-2'-deoxycytidine inhibited cell growth in vitro in L1210 mouse leukemic cells (concentration causing 50% inhibition about 1 X 10(-6) M) and was also active in vivo in increasing the life span of mice with L1210 leukemia by 100% after a single i.p. injection (800 to 1000 m...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6207913

データ提供：米国国立医学図書館（NLM）

Alpha-D-Anomer of 5-Aza-2'-Deoxycytidine: A Hopeful Oasis in the Desert of Leukemia

Leukemia, a cancer of the blood-forming tissues, can be a formidable adversary, leaving patients yearning for effective treatments. This study, published in 1984, explores the potential of the alpha-D-anomer of 5-aza-2'-deoxycytidine, a modified nucleoside, as a therapeutic agent against L1210 mouse leukemic cells. The researchers investigated the drug's in vitro and in vivo effects on cell growth and survival, comparing its activity and toxicity to that of its parent compound, 5-aza-2'-deoxycytidine.

A Promising Oasis in the Desert of Leukemia

The study revealed that the alpha-D-anomer of 5-aza-2'-deoxycytidine effectively inhibited cell growth in vitro and significantly prolonged the lifespan of mice with L1210 leukemia in vivo. Moreover, the drug exhibited significantly less host toxicity compared to its parent compound. Think of the alpha-D-anomer as a hidden spring in the heart of the desert, offering a lifeline to those struggling with the harsh realities of leukemia.

A New Path Forward

This research suggests that the alpha-D-anomer of 5-aza-2'-deoxycytidine holds promise as a potential therapeutic agent for leukemia, potentially offering a safer and more effective alternative to existing treatments. This study is a reminder that the desert of cancer research is vast and complex, but the potential for groundbreaking discoveries is boundless.

Dr.Camel's Conclusion

This study provides promising evidence for the potential of the alpha-D-anomer of 5-aza-2'-deoxycytidine as a therapeutic agent against leukemia. While further research is needed, this study offers hope for a more effective and less toxic treatment option for patients battling this debilitating disease. This is a testament to the enduring spirit of scientific inquiry, constantly seeking new paths in the desert of cancer research, with the goal of finding a cure.

Date :
  1. Date Completed 1984-11-28
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

6207913

DOI: Digital Object Identifier

6207913

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English

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