Viloxazine plasma concentrations and clinical response.

Author: BurrowsG D, DaviesB M, MaguireK P, NormanT R, WurmJ M

Paper Details 
Original Abstract of the Article :
Eleven patients suffering from primary depressive illness were treated with 300 mg/d of viloxazine for 29 days. Blood samples were collected at weekly intervals and severity of depression assessed using the Hamilton depression rating scale. Mean plasma viloxazine level for all patients during the tr...See full text at original site
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引用元:
https://doi.org/10.1016/0165-0327(80)90002-6

データ提供:米国国立医学図書館(NLM)

Exploring the Relationship Between Viloxazine Levels and Depression Treatment

The study of depression is like navigating a vast desert, filled with complex emotions and intricate pathways. Researchers embarked on a journey to understand the connection between viloxazine levels and its effectiveness in treating depression. They carefully monitored eleven individuals diagnosed with primary depressive illness over a 29-day period, tracking their plasma viloxazine levels and their response to treatment, measured using the Hamilton Depression Rating Scale.

This study was conducted in a controlled setting, like a carefully curated oasis in the desert. Participants received a consistent dosage of viloxazine (300 mg/day) for the entire duration of the study, allowing researchers to analyze the relationship between drug levels and clinical improvement. The results, however, revealed a complex picture. While researchers observed a range of plasma viloxazine levels, they didn't find a clear correlation between the level of the medication in the blood and the level of depression improvement. This suggests that the relationship between drug levels and therapeutic response is not straightforward, and other factors might play a crucial role.

No Simple Answers in the Desert of Depression

This study underscores the complexity of depression and its treatment. The lack of a direct correlation between viloxazine levels and symptom improvement suggests that the relationship between medication and therapeutic response is not a simple one. Other factors, such as individual patient characteristics and the underlying mechanisms of depression, might play a significant role in determining treatment outcomes. This study, like a carefully observed oasis, provides valuable insights, emphasizing the need for further investigation and personalized treatment approaches.

The Journey Continues

This study, like a journey through the desert, reveals that there are no simple answers when it comes to treating depression. While viloxazine may be a helpful tool, further research is needed to understand the intricate interplay between medication levels, individual patient characteristics, and the underlying mechanisms of depression. This knowledge will guide us toward more personalized treatment strategies that are tailored to each individual's unique journey in the desert of depression.

Dr.Camel's Conclusion

The study of depression is a continuous journey through a vast desert, filled with intricate pathways and complex emotions. This study, like a carefully observed oasis, highlights the need for further exploration and personalized approaches to effectively navigate the challenges of depression and find the most effective treatment strategies for each individual.

Date :
  1. Date Completed 1982-07-19
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

6210721

DOI: Digital Object Identifier

10.1016/0165-0327(80)90002-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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