Effects of prochlorperazine on experimental nephrotoxicity.

Author: CoxJ L, GilesR C, HarrisonS D

Paper Details 
Original Abstract of the Article :
In early studies of the antitumor drug 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1nitrosourea (methyl-CCNU), animal models consistently predicted that the compound would be nephrotoxic in humans. Nephrotoxicity in cancer patients who had received methyl-CCNU was not confirmed until about 6 years afte...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1007/BF00257241

データ提供:米国国立医学図書館(NLM)

Prochlorperazine: A Potential Protector Against Nephrotoxicity?

The field of [nephrotoxicity] is a complex one, and understanding the mechanisms that lead to kidney damage is crucial for patient care. This study explores the potential protective role of [prochlorperazine], a commonly used [antiemetic], against [nephrotoxicity] induced by [methyl-CCNU] and [mercuric chloride]. The researchers utilized [animal models] to investigate the effects of [prochlorperazine] on [nephrotoxicity] and discovered that it significantly reduced the frequency and severity of renal lesions in both mice and rats.

Prochlorperazine: A Potential Shield for the Kidneys

The study found that [prochlorperazine] significantly reduced the [concentrations of plasma urea nitrogen] in mice that received [methyl-CCNU] and inhibited [urinary excretion of N-acetylglucosaminidase and leucine aminopeptidase] in rats that received [mercuric chloride]. This suggests that [prochlorperazine] might be able to protect the kidneys from damage caused by these nephrotoxins.

Prochlorperazine: A Protective Oasis in the Desert of Nephrotoxicity

This study provides a glimpse into the potential benefits of [prochlorperazine] in protecting the kidneys from damage caused by [nephrotoxins]. While further research is needed to fully understand the mechanisms involved, this research suggests that [prochlorperazine] could potentially be a valuable tool in managing and preventing [nephrotoxicity] in certain situations. As a researcher, I am always fascinated by the delicate balance in our bodies – and how even a small change, like the use of [prochlorperazine], can have a significant impact on health.

Dr.Camel's Conclusion

The findings of this study suggest that prochlorperazine may offer protection against nephrotoxicity induced by certain drugs. Further investigation is needed to clarify the mechanisms of action and determine the full potential of this medication.

Date :
  1. Date Completed 1983-04-15
  2. Date Revised 2019-08-29
Further Info :

Pubmed ID

6218930

DOI: Digital Object Identifier

10.1007/BF00257241

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.