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Original Abstract of the Article :
In early studies of the antitumor drug 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1nitrosourea (methyl-CCNU), animal models consistently predicted that the compound would be nephrotoxic in humans. Nephrotoxicity in cancer patients who had received methyl-CCNU was not confirmed until about 6 years afte...See full text at original site
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引用元:
https://doi.org/10.1007/BF00257241
データ提供:米国国立医学図書館(NLM)
Prochlorperazine: A Potential Protector Against Nephrotoxicity?
The field of [nephrotoxicity] is a complex one, and understanding the mechanisms that lead to kidney damage is crucial for patient care. This study explores the potential protective role of [prochlorperazine], a commonly used [antiemetic], against [nephrotoxicity] induced by [methyl-CCNU] and [mercuric chloride]. The researchers utilized [animal models] to investigate the effects of [prochlorperazine] on [nephrotoxicity] and discovered that it significantly reduced the frequency and severity of renal lesions in both mice and rats.
Prochlorperazine: A Potential Shield for the Kidneys
The study found that [prochlorperazine] significantly reduced the [concentrations of plasma urea nitrogen] in mice that received [methyl-CCNU] and inhibited [urinary excretion of N-acetylglucosaminidase and leucine aminopeptidase] in rats that received [mercuric chloride]. This suggests that [prochlorperazine] might be able to protect the kidneys from damage caused by these nephrotoxins.
Prochlorperazine: A Protective Oasis in the Desert of Nephrotoxicity
This study provides a glimpse into the potential benefits of [prochlorperazine] in protecting the kidneys from damage caused by [nephrotoxins]. While further research is needed to fully understand the mechanisms involved, this research suggests that [prochlorperazine] could potentially be a valuable tool in managing and preventing [nephrotoxicity] in certain situations. As a researcher, I am always fascinated by the delicate balance in our bodies – and how even a small change, like the use of [prochlorperazine], can have a significant impact on health.
Dr.Camel's Conclusion
The findings of this study suggest that prochlorperazine may offer protection against nephrotoxicity induced by certain drugs. Further investigation is needed to clarify the mechanisms of action and determine the full potential of this medication.
Date :
- Date Completed 1983-04-15
- Date Revised 2019-08-29
Further Info :
Related Literature
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