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Effects of moxalactam and cefuroxime on mitogen-stimulated human mononuclear leukocytes.
Author: ClarkJ K, ManzellaJ P
Original Abstract of the Article :
The effect of moxalactam and cefuroxime on mitogen-stimulated human peripheral blood mononuclear leukocytes was studied. Mononuclear leukocytes, mitogen, and antibiotic were added to microtiter wells. Cells were cultured for 3 days, pulsed with tritiated thymidine, and then counted. Compared with co...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1128/AAC.23.3.360
データ提供:米国国立医学図書館(NLM)
Effects of Moxalactam and Cefuroxime on Immune Cells
This study takes a closer look at the effects of antibiotics on the immune system, which is a complex and delicate ecosystem within our bodies, much like a desert ecosystem. The researchers focused on moxalactam and cefuroxime, two beta-lactam antibiotics, and their impact on human mononuclear leukocytes, which are essential components of our immune defense.
Immune Suppression: A Desert Oasis With a Hidden Danger
The study found that these antibiotics, at concentrations achievable in serum during therapeutic use, may have immunosuppressant effects. This is a bit like a desert oasis that appears inviting but harbors a hidden danger. The study highlighted that moxalactam and cefuroxime, even at therapeutic doses, can suppress the immune response to mitogens, which are like triggers that activate immune cells.
Impact on Immune Function: A Desert Mirage
While the study’s findings suggest a potential for immunosuppression, it’s important to emphasize that further research is needed to determine the clinical significance of these effects. It’s like a desert mirage; it may appear promising, but it’s crucial to examine it closely before concluding anything definite.
Dr. Camel's Conclusion
This study raises important questions about the potential immunosuppressant effects of moxalactam and cefuroxime. It serves as a reminder that even seemingly innocuous substances can have unexpected effects on our complex biological systems. Further research is needed to determine the clinical implications of these findings. It’s a journey through the desert of scientific exploration, where vigilance and continued research are essential.
Date :
- Date Completed 1983-06-10
- Date Revised 2021-05-26
Further Info :
Related Literature
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