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Probucol with colestipol in the treatment of hypercholesterolemia.

Author: ChernoffS B, DecourseyS, DujovneC A, GartyM, JacksonB, KrehbielP, PittermanA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Probucol and colestipol combined were more effective in reducing LDL cholesterol levels than either drug alone, with fewer side effects.
Paper Details　
Original Abstract of the Article :
The effects of therapy with 1 g of probucol and 20 g of colestipol were compared with those of the drugs used singly on 47 patients with hypercholesterolemia in a double-blind, double-placebo, diet-controlled, crossover trial that lasted 18 months. The probucol and colestipol combination, but neithe...See full text at original site
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引用元：
https://doi.org/10.7326/0003-4819-100-4-477

データ提供：米国国立医学図書館（NLM）

Probucol and Colestipol: A Powerful Duo for Lowering Cholesterol

[Hypercholesterolemia], a condition marked by high cholesterol levels, is a major risk factor for cardiovascular disease. This study delves into the effectiveness of combining [probucol and colestipol] in managing hypercholesterolemia. The authors conducted a [double-blind, double-placebo, diet-controlled, crossover trial] to compare the effects of this combination with those of each drug used alone. This research provides insights into the potential benefits of this combination therapy in lowering cholesterol levels and reducing the risk of cardiovascular disease.

A Powerful Combination: Probucol and Colestipol

The study found that the combination of probucol and colestipol was significantly more effective in lowering [low-density lipoprotein (LDL) cholesterol] than either drug alone. This combination therapy also resulted in a reduction in [gastrointestinal side effects], making it a more tolerable treatment option for many patients.

Heart Health: Taking Control of Cholesterol

This study highlights the potential of combining probucol and colestipol for effective management of hypercholesterolemia. It's important to consult with your healthcare provider to determine if this combination therapy is right for you.

Dr.Camel's Conclusion

The desert of heart health is vast and complex, but research continues to illuminate new pathways to preventing and managing cardiovascular disease. This study demonstrates the potential of effective combination therapies to improve patient outcomes and reduce the risk of heart disease.

Date :
  1. Date Completed 1984-04-12
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

6367578

DOI: Digital Object Identifier

10.7326/0003-4819-100-4-477

Related Literature

Article Analysis
・Side Effects of colestipol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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