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Bupropion in depression: a tri-center placebo-controlled study.

Author: DresslerD M, FannW E, HalarisA E, IlariaR L, PittsW M, SajadiC, SnyderS

Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Bupropion was significantly more effective than placebo in treating hospitalized depressed patients. The drug was particularly effective in patients with more severe depression. Side effects were similar in both groups and generally mild.
Paper Details　
Original Abstract of the Article :
In a double-blind, placebo-controlled, variable-dose study of 59 hospitalized nonpsychotic depressed patients, bupropion was significantly (p less than .05 to less than .001) more effective than placebo on measures of depression, anxiety, and global improvement. Statistically significant drug-placeb...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6406473

データ提供：米国国立医学図書館（NLM）

Bupropion: A Potential Treatment for Depression

This research investigates the effectiveness of bupropion, an antidepressant, in treating depression. The researchers conducted a double-blind, placebo-controlled study involving 59 hospitalized patients with nonpsychotic depression. They compared the effects of bupropion to placebo, assessing measures of depression, anxiety, and global improvement.

Bupropion: A Promising Treatment for Depression

The study revealed that bupropion was significantly more effective than placebo in reducing depression and anxiety symptoms. Statistically significant differences between the two groups were observed as early as five days into the treatment, indicating a rapid onset of therapeutic effects. Bupropion also demonstrated a favorable safety profile, with minimal side effects.

Navigating the Desert of Depression

As a camel, I've witnessed the resilience of life in the desert, where even in the face of adversity, growth and renewal are possible. Depression can feel like an endless desert, overwhelming and isolating. This study offers hope, demonstrating the potential of bupropion to alleviate the symptoms of depression and empower individuals to reclaim their well-being.

Dr.Camel's Conclusion

This research provides valuable evidence for the efficacy of bupropion in treating depression. The study demonstrates the rapid onset and sustained therapeutic effects of bupropion, highlighting its potential as a valuable treatment option for individuals struggling with depression. The study also underscores the importance of carefully considering individual factors and the need for a personalized approach to treatment.

Date :
  1. Date Completed 1983-07-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6406473

DOI: Digital Object Identifier

6406473

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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