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Amoxapine and amitriptyline. II. Specificity of cognitive effects during brief treatment of depression.

Author: FaldettaL L, FrankenthalerL M, KahnR J, McNairD M

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Amitriptyline and amoxapine had different cognitive effects in depressed outpatients. Amitriptyline improved reaction time and immediate memory, while amoxapine slowed performance and increased intrapersonal variability on a psychomotor task. Both drugs increased pulse rate and reduced palmar sweating.
Paper Details　
Original Abstract of the Article :
Cognitive effects of brief antidepressant treatments were studied in depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline in a 12-week double-crossover of 3-week periods of active agent and placebo. The two drugs had different profiles of effects: amitriptyli...See full text at original site
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引用元：
https://doi.org/10.1007/BF00429721

データ提供：米国国立医学図書館（NLM）

Amoxapine and Amitriptyline: Navigating the Desert of Depression Treatment

The journey through the desert of [depression] can be arduous, often requiring the support of [antidepressant medications]. This study compares two commonly used antidepressants, [amoxapine] and [amitriptyline], focusing on their cognitive effects in patients undergoing brief treatment. The researchers conducted a [double-blind, crossover study] to assess the cognitive impact of these medications, revealing distinct profiles of effects. While amitriptyline appeared to enhance attention and immediate memory, amoxapine exhibited a different pattern, impacting psychomotor coordination. These findings suggest that the choice of antidepressant may influence cognitive function, further emphasizing the need for personalized approaches to depression treatment.

Amoxapine and Amitriptyline: A Tale of Two Antidepressants

This study reveals distinct cognitive effects associated with amoxapine and amitriptyline, emphasizing the need for personalized approaches to depression treatment. While amitriptyline appeared to enhance attention and immediate memory, amoxapine showed a different pattern, impacting psychomotor coordination. These findings suggest that careful consideration of cognitive effects may be warranted when selecting an antidepressant.

Navigating the Desert of Depression Treatment: Seeking Personalized Support

The journey through the desert of depression can be individualized, requiring tailored treatment approaches. This study highlights the potential differences in cognitive effects associated with different antidepressants, reminding us that a personalized approach may be essential for optimal outcomes. Open communication with your healthcare provider is crucial in selecting a treatment plan that meets your individual needs.

Dr. Camel's Conclusion

This research reminds us that the desert of depression treatment is vast and complex, with different medications offering distinct effects. Just as a traveler carefully considers the terrain and chooses the appropriate gear for the journey, individuals with depression should work with their healthcare provider to select a treatment approach that best suits their individual needs and circumstances.

Date :
  1. Date Completed 1984-09-20
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6431462

DOI: Digital Object Identifier

10.1007/BF00429721

Related Literature

Article Analysis
・Effects of amoxapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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