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Trials of single-agent and combination chemotherapy for advanced cancer of the pancreas.
Author: BrodovskyH, DouglassH, EngstromP, FalksonG, GelberR D, HortonJ, MoertelC
Original Abstract of the Article :
In a study of 127 patients with advanced measurable pancreatic cancer, objective response rates of 2% (melphalan), 10% (5-FU and methyl-CCNU), and 7% (5-FU, methyl-CCNU, and streptozocin) were achieved. No responses occurred in the 28 patients treated with VP-16-213 who had already received prior ch...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/6452948
データ提供:米国国立医学図書館(NLM)
Battling Pancreatic Cancer: A Desert Storm
Pancreatic cancer is a formidable foe, akin to a relentless desert storm. This study focuses on the use of chemotherapy in patients with advanced pancreatic cancer, a battle that requires a strategic approach. The researchers investigated the effectiveness of single-agent and combination chemotherapy regimens, exploring different combinations of medications to find the most effective strategy. They evaluated response rates, toxicity, and survival outcomes, aiming to identify a winning combination in this challenging fight.
The study involved 127 patients, a considerable number considering the rarity of this disease. The researchers observed modest response rates to various regimens, highlighting the difficulty of combating this aggressive cancer. They also noted that toxicity levels were higher with combination therapy than with single-agent treatment, a reminder that even the most potent weapons can come with their own dangers. Ultimately, the study concluded that further research is necessary to develop effective chemotherapy for patients with pancreatic cancer, emphasizing the need for continued exploration and innovation in this field.
The Need for New Weapons in the Desert
The findings of this study underscore the need for new and innovative approaches to treating pancreatic cancer. The low response rates and significant toxicities associated with current chemotherapy regimens illustrate the limitations of existing treatments. This research serves as a call to action, urging researchers to develop more effective and less toxic therapies for this challenging disease.
Hope in the Desert
While the fight against pancreatic cancer remains arduous, this research provides a reminder that hope is still alive. The persistence of researchers and their unwavering commitment to finding a cure offer a beacon of light in this challenging desert. By continuing to explore new avenues of treatment and improving existing therapies, we can bring hope and relief to those battling this formidable foe.
Dr. Camel's Conclusion
Despite the challenges, this study emphasizes the importance of continued research in the fight against pancreatic cancer. The journey may be long and arduous, but the pursuit of effective therapies remains a critical priority. Like a desert oasis, breakthroughs in research offer much-needed hope and relief in the face of this relentless foe.
Date :
- Date Completed 1981-07-20
- Date Revised 2013-11-21
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English
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