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Safety and therapeutic effectiveness of 8-methoxypsoralen, 4,5',8-trimethylpsoralen, and psoralen in vitiligo.

Author: FitzpatrickT B, MosherD B, PathakM A

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

In a double-blind study of 366 East Indian patients with vitiligo, treatment with 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP), or psoralen and sunlight for 2-3 years resulted in full repigmentation of the face in 45% of patients receiving a combination of 8-MOP and TMP or low-dose 8-MOP. Nearly 60% of patients achieved 75-100% repigmentation of the head and neck. The chest, abdomen, and back showed good repigmentation, while the arms and legs showed less improvement. Higher doses of TMP and psoralen resulted in better repigmentation than lower doses, but not as good as 8-MOP or the combination group.
Paper Details　
Original Abstract of the Article :
In this paper, we report on 366 East Indian patients with vitiligo who were treated for 2 to 3 years with either 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP), or psoralen and sunlight. These patients with amelanotic macules had 10 to 70% skin involvement of 1 to 50 years duration. Male ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/6531024

データ提供：米国国立医学図書館（NLM）

Vitiligo Treatment: Finding the Path to Repigmentation

The field of [dermatology] is dedicated to understanding and treating skin conditions, including vitiligo, a disorder characterized by depigmentation of the skin. This study investigates the effectiveness of different psoralen-based therapies in treating vitiligo. The study utilized a [double-blind, randomized controlled trial] design to compare the efficacy of 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP), and psoralen in combination with sunlight exposure. The researchers found that [the combination therapy of 8-MOP and TMP, as well as low-dose 8-MOP, resulted in significant repigmentation in patients with vitiligo].

Finding the Oasis of Repigmentation: Psoralen-Based Therapies

This study provides valuable information for patients with vitiligo, showing that [psoralen-based therapies can be effective in restoring skin pigmentation]. The researchers discovered that [certain combinations and dosages of psoralen were particularly effective], offering hope for those seeking to improve the appearance and quality of life affected by vitiligo. It's like finding a hidden oasis in the desert of vitiligo, offering a path towards repigmentation and a sense of normalcy.

Navigating the Desert of Vitiligo: Understanding Treatment Options

Living with vitiligo can be like navigating a desert landscape, marked by patches of depigmentation and a sense of uncertainty. This study sheds light on the potential benefits of psoralen-based therapies, offering hope for those seeking to improve their skin condition. It is important to [consult with a dermatologist] to discuss individual treatment options and potential risks associated with psoralen therapy.

Dr.Camel's Conclusion

This study highlights the potential of psoralen-based therapies to improve the appearance and quality of life for patients with vitiligo. It's like discovering a secret oasis in the desert of skin conditions, offering a path towards repigmentation and a brighter outlook. While further research is needed to optimize treatment approaches, this study offers hope for those seeking relief from the challenges of vitiligo.

Date :
  1. Date Completed 1985-05-14
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

6531024

DOI: Digital Object Identifier

6531024

Related Literature

Article Analysis
・Effective treatment of vitiligo
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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