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Experimental pneumonia due to Haemophilus influenzae: observations on pathogenesis and treatment.
Author: EspositoA L, PenningtonJ E
Original Abstract of the Article :
A model of pneumonia due to Haemophilus influenzae type b was developed in mice and used for exploration of the pathophysiology of the infection and evaluation of the efficacy of five antimicrobial agents. Adult C57BL/6 mice were challenged with 3 X 10(9) cfu of H influenzae by intratracheal inocula...See full text at original site
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引用元:
https://doi.org/10.1093/infdis/149.5.728
データ提供:米国国立医学図書館(NLM)
Conquering Haemophilus influenzae: A Mouse Model for Pneumonia
Haemophilus influenzae type b, a common cause of pneumonia, can be a formidable foe, leading to serious respiratory infections. This study explores the pathogenesis of this infection and the efficacy of various antibiotics in combating it. The researchers created a mouse model of pneumonia, allowing them to study the infection process and test the effectiveness of different drugs. They infected mice with H. influenzae type b and then treated them with various antibiotics, including ampicillin, cefamandole, chloramphenicol, erythromycin plus sulfisoxazole, and fludalanine plus pentizidone. Their findings indicate that ampicillin emerged as the most effective antibiotic, quickly eradicating bacteria from the lungs and improving survival rates.
Ampicillin: A Mighty Weapon Against Pneumonia
This study demonstrates the superior efficacy of ampicillin in treating pneumonia caused by H. influenzae type b. The results highlight the importance of selecting the right antibiotic for optimal treatment outcomes.
A Journey Through the Labyrinth of Infection
This research provides a valuable roadmap for understanding the pathogenesis of H. influenzae pneumonia and for selecting the most effective antibiotic treatment. It's like exploring a vast desert of bacterial infections, seeking the right tools and strategies to combat these troublesome invaders. This study serves as a reminder of the importance of carefully selecting the appropriate antibiotics, ensuring we have the right weapons to fight these unseen enemies.
Dr.Camel's Conclusion
This study emphasizes the crucial role of antibiotic selection in effectively combating H. influenzae pneumonia. The researchers' meticulous exploration of this infection and its treatment provides valuable insights, highlighting the importance of choosing the right antibiotic, like a skilled desert navigator selecting the best path for a successful journey.
Date :
- Date Completed 1984-07-18
- Date Revised 2019-05-11
Further Info :
Related Literature
English
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