Paper Details

  1. Home
  2. Paper Details

Prolactin stimulating effects of amoxapine and loxapine in psychiatric patients.

Author: BerryR, MeltzerH Y, RobertsonA G

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Amoxapine increased serum prolactin levels. This suggests that amoxapine blocks dopamine receptors at the anterior pituitary.
Paper Details　
Original Abstract of the Article :
The effects of acute and chronic administration of a new antidepressant, amoxapine, on serum prolactin levels were compared to the effects of loxapine, its parent compound, which is a widely used neuroleptic. Serum prolactin levels were significantly elevated after amoxapine. These elevations were n...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/BF00428168

データ提供：米国国立医学図書館（NLM）

Prolactin Stimulating Effects of Amoxapine and Loxapine in Psychiatric Patients

The use of [antidepressants and neuroleptics] in the treatment of psychiatric disorders has become increasingly refined. This study investigates the effects of [amoxapine and loxapine] on [serum prolactin levels] in psychiatric patients. It seeks to understand the mechanisms of action of these drugs and their potential impact on hormone regulation. This research is a step towards understanding the complex interplay between medication and the human body, offering valuable insights into the therapeutic and potential side effects of these treatments.

The Impact of Amoxapine and Loxapine on Prolactin Levels

The study found that both amoxapine and loxapine significantly elevated serum prolactin levels. This finding suggests that both medications, unlike many other antidepressants, can block dopamine receptors at the anterior pituitary. The implications of these findings for the clinical use of amoxapine are discussed.

Understanding Medication Effects: Informed Decision-Making

This study emphasizes the importance of understanding the full spectrum of effects associated with medication, including potential hormonal changes. This knowledge is crucial for informed decision-making regarding treatment options, particularly in the context of psychiatric medications where the potential for hormonal side effects is a factor.

Dr.Camel's Conclusion

This research is like a wise old camel, sharing its knowledge of the intricate workings of the human body. By revealing the impact of amoxapine and loxapine on prolactin levels, it sheds light on the potential side effects of these medications. This understanding empowers clinicians to make informed decisions regarding treatment and monitor patient well-being closely.

Date :
  1. Date Completed 1983-03-24
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6818584

DOI: Digital Object Identifier

10.1007/BF00428168

Related Literature

Article Analysis
・Effects of amoxapine・Effects of loxapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.