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Pharmacodynamic and pharmacokinetic interactions between ketamine and diazepam.
Author: AronsenK F, IdvallJ, PaalzowL, StenbergP
Original Abstract of the Article :
Anaesthesia with continuous i.v. ketamine and 65% nitrous oxide in oxygen was given to a total of 49 patients undergoing major abdominal surgery. A control group was premedicated with atropine and other groups received in addition rectal diazepam or clorazepate i.v. For further patients had been on ...See full text at original site
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引用元：
https://doi.org/10.1007/BF00610051
データ提供：米国国立医学図書館（NLM）
Ketamine and Diazepam: A Complex Interaction in the Desert of Anesthesia
The field of [anesthesia] is constantly exploring new drug combinations and strategies to optimize patient care and minimize complications. This study investigates the [pharmacokinetic] and [pharmacodynamic] interactions between [ketamine] and [diazepam] during [general anesthesia] for [major abdominal surgery]. The authors examined the effects of [diazepam premedication] on the [hemodynamic] and [psychotomimetic] effects of [ketamine] during [general anesthesia].
Diazepam: A Modulator of Ketamine Effects
The study found that [diazepam premedication] significantly reduced the [hemodynamic stimulation] associated with [ketamine], while not significantly affecting the [psychotomimetic effects]. This suggests that [diazepam] can modulate the effects of [ketamine] during [general anesthesia], potentially reducing the risk of unwanted side effects. The study also revealed interesting metabolic interactions between the two drugs, highlighting the importance of understanding these interactions for optimizing patient care.
Navigating the Shifting Sands of Anesthesia
The desert of [anesthesia] is a complex landscape, requiring careful consideration of drug interactions and patient factors. This study sheds light on the potential benefits of [diazepam premedication] in reducing the [hemodynamic stimulation] associated with [ketamine] during [general anesthesia]. This research provides valuable insights for clinicians seeking to optimize anesthetic protocols and ensure the best possible outcomes for their patients.
Dr.Camel's Conclusion
This study highlights the complex [pharmacokinetic] and [pharmacodynamic] interactions between [ketamine] and [diazepam] during [general anesthesia]. The findings suggest that [diazepam premedication] can effectively reduce the [hemodynamic stimulation] associated with [ketamine], potentially improving patient safety and comfort during surgical procedures. This research contributes to a deeper understanding of the intricate relationships between anesthetic drugs, paving the way for more effective and personalized anesthetic management.
Date :
- Date Completed 1983-08-11
- Date Revised 2019-08-13
Further Info :
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