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Pharmacokinetics and clinical effects of cefuroxime in patients with severe renal insufficiency.

Author: BergK J, NilsenO G, WalstadR A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cefuroxime was effective in treating urinary tract infections in patients with severe renal impairment. The drug was well tolerated and showed a good clinical efficacy.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics and clinical effects of cefuroxime were investigated in 5 patients with severe impairment of renal function (creatinine clearance less than or equal to 23 ml/min), suffering from an urinary tract infection. Bolus i.v. injections of cefuroxime 750 mg b.i.d. or 750 mg once daily w...See full text at original site
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引用元：
https://doi.org/10.1007/BF00610061

データ提供：米国国立医学図書館（NLM）

Cefuroxime: A Desert Oasis for Urinary Tract Infections

This study investigates the pharmacokinetics and clinical effects of cefuroxime, an antibiotic, in patients with severe renal insufficiency. Renal insufficiency, like a drought in the desert, can impair the body's ability to eliminate waste products, including medications. This study explores how cefuroxime behaves in the body in this challenging context.

Cefuroxime: Navigating the Sands of Renal Insufficiency

The study shows that cefuroxime is effective in treating urinary tract infections even in patients with severe renal insufficiency. However, the drug's elimination half-life is significantly prolonged in these patients, highlighting the importance of adjusting dosage and monitoring for potential side effects.

Cefuroxime: A Beacon of Hope for Patients with Renal Insufficiency

Cefuroxime, like a camel's ability to thrive in the desert, can be an effective treatment for urinary tract infections even in patients with severe renal insufficiency. This study emphasizes the importance of careful monitoring and dose adjustments in these patients to ensure safe and effective treatment. The researchers highlight the need for ongoing research to develop optimal antibiotic regimens for patients with renal insufficiency.

Dr.Camel's Conclusion

This study provides valuable insights into the use of cefuroxime in patients with severe renal insufficiency. It highlights the importance of careful monitoring and dose adjustments to ensure safe and effective treatment. The findings underscore the need for personalized medicine approaches to account for individual patient characteristics, particularly in cases of renal insufficiency.
Date :
  1. Date Completed 1983-08-11
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

6861853

DOI: Digital Object Identifier

10.1007/BF00610061

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SNS
PICO Info
in preparation
Languages

English

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