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HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.

Author: BardinT, DaussetJ, DebeyreN, DryllA, LegrandL, MarcelliA, RyckewaertA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Patients with the HLA haplotype A1 Cw7 B8 DR3 are more likely to experience gold toxic reactions.
Paper Details　
Original Abstract of the Article :
Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlatio...See full text at original site
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引用元：
https://doi.org/10.1136/ard.41.6.599

データ提供：米国国立医学図書館（NLM）

HLA System and Side Effects of Gold Salts and D-penicillamine Treatment for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can significantly impact quality of life. This study investigates the relationship between specific HLA antigens and the occurrence of side effects from gold salts and D-penicillamine, two medications used to treat RA. It's like a detective story, piecing together clues to understand the underlying mechanisms of drug response in patients with RA.

HLA Antigens: A Potential Indicator of Drug Response

The study found a significant correlation between the presence of certain HLA antigens, such as A1, B8, Cw7, and DR3, and the likelihood of experiencing side effects from gold salts. This suggests that HLA antigens may be a useful marker for predicting drug response and tailoring treatment plans for RA patients. This is like discovering a map that reveals specific pathways through the desert, guiding us toward safer and more effective treatment strategies.

Personalized Medicine: A Key to Effective Treatment

This research reinforces the importance of personalized medicine, tailoring treatment plans to the individual's unique genetic makeup. Understanding the role of HLA antigens in drug response can help healthcare professionals make informed decisions about medication choices, minimizing the risk of side effects and maximizing the effectiveness of treatment. Just as a camel adapts its travel route based on the specific desert terrain, we can learn to navigate the complexities of RA treatment by considering individual differences and genetic factors.

Dr.Camel's Conclusion

This study highlights the potential of HLA antigens as a valuable tool for predicting drug response in rheumatoid arthritis. It underscores the importance of personalized medicine and the ongoing search for biomarkers that can guide effective treatment strategies. Remember, like a camel that navigates the desert with an innate understanding of its environment, we can learn to approach healthcare with a personalized and adaptable approach.

Date :
  1. Date Completed 1983-01-19
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

6959574

DOI: Digital Object Identifier

10.1136/ard.41.6.599

Related Literature

Article Analysis
・Side Effects of penicillamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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