Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea.

Author: CorbettC L, HoldsworthC D, PalmerK R

Paper Details 
Original Abstract of the Article :
As no adequate comparison of these widely used drugs has been made, we have performed a double-blind cross-over trial in 30 individuals with chronic diarrhea. Each underwent three randomized treatment periods of 4 wk duration. Patients were instructed to increase the daily dose gradually until contr...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/7002706

データ提供:米国国立医学図書館(NLM)

Loperamide, Codeine, and Diphenoxylate: A Comparison of Chronic Diarrhea Treatments

Chronic diarrhea can be a real pain, and finding the right medication to manage it can feel like a desert search for a reliable oasis. This research compares the effectiveness of three commonly used medications: loperamide, codeine, and diphenoxylate. The study found that all three drugs were effective in reducing stool frequency, but loperamide and codeine were more effective in relieving urgency and fecal incontinence. Diphenoxylate, however, proved less effective in producing solid stools. The study also observed that diphenoxylate had the most side effects, particularly central nervous effects, while loperamide had the fewest. The study concludes that loperamide and codeine phosphate are superior to diphenoxylate in the symptomatic treatment of chronic diarrhea.

Loperamide and Codeine: Finding Relief for Chronic Diarrhea

This study provides valuable insights into the effectiveness of different medications for chronic diarrhea. The findings suggest that loperamide and codeine may be preferable options to diphenoxylate, offering greater relief from symptoms like urgency and fecal incontinence. This research highlights the importance of personalized treatment plans, considering individual patient needs and preferences to find the most effective and well-tolerated medication.

Navigating the Desert of Chronic Diarrhea: Finding the Right Medication

Chronic diarrhea can feel like a never-ending journey through a sandy desert, with unpredictable twists and turns. This study offers a helpful guide for navigating the terrain, highlighting the potential benefits and drawbacks of different medications. The study underscores the importance of understanding the individual needs and preferences of each patient, as well as potential side effects, to find the right medication for a smoother and more comfortable journey.

Dr.Camel's Conclusion

This study offers a comparison of three medications commonly used to treat chronic diarrhea. Loperamide and codeine phosphate emerge as superior options, demonstrating greater effectiveness in controlling symptoms and fewer side effects. It's important to remember that finding the right medication is a journey, and working closely with your doctor to tailor your treatment plan is crucial. Just like a camel navigating a desert, finding the right path to relief often involves a mix of patience, adaptability, and a willingness to explore different options.

Date :
  1. Date Completed 1981-02-19
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

7002706

DOI: Digital Object Identifier

S0016508580002454

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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