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Dipivefrin: current concepts.

Author: BeckerB, GoldbergI, KassM A, KolkerA E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Dipivefrin, a pro-drug of epinephrine, was found to be a safe and effective alternative to epinephrine in treating elevated intraocular pressure. It is particularly useful for patients who cannot tolerate epinephrine.
Paper Details　
Original Abstract of the Article :
Pro-drugs are agents that require biotransformation prior to exhibiting pharmacologic activity. Dipivefrin (dipivalyl epinephrine or DPE) is an epinephrine pro-drug produced by the addition of two pivalic acid groups to the parent compound. This creates a more lipophilic molecule which penetrates th...See full text at original site
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引用元：
https://doi.org/10.1111/j.1442-9071.1980.tb01673.x

データ提供：米国国立医学図書館（NLM）

Dipivefrin: A Refreshing Oasis in the Desert of Glaucoma

Glaucoma, a condition that silently steals vision, is a formidable foe in the desert of ophthalmology. This study, like a traveler discovering a hidden oasis, explores the potential of dipivefrin, a prodrug of epinephrine, in the treatment of elevated intraocular pressure (IOP), a key risk factor for glaucoma. Dipivefrin, due to its enhanced lipophilicity, can penetrate the cornea more effectively than epinephrine, leading to similar reductions in IOP with fewer side effects. This research offers a promising approach for managing IOP without compromising patient comfort.

A Refreshing Oasis: Dipivefrin's Potential in Glaucoma Management

Dipivefrin's effectiveness in reducing IOP, coupled with its favorable side effect profile, presents a valuable alternative to epinephrine, especially for patients who experience intolerance to the parent compound. This study reinforces the importance of personalized treatment approaches, tailored to individual patient needs, and highlights the ongoing pursuit of new solutions for the treatment of glaucoma. Dipivefrin offers a refreshing oasis in the desert of glaucoma management.

Sipping from the Oasis: Managing Glaucoma with Dipivefrin

The desert of glaucoma management demands vigilance and a commitment to regular eye exams. Dipivefrin offers a promising oasis for managing IOP but should not be considered a cure. Patients should continue to follow their doctor's recommendations for eye care, including regular monitoring of IOP and any changes in vision. With careful management and a proactive approach, patients can navigate the desert of glaucoma and protect their vision.

Dr. Camel's Conclusion

The desert of glaucoma management is a challenging landscape, but research continues to unveil new oases of hope. Dipivefrin, with its effective IOP reduction and favorable side effect profile, provides a refreshing alternative for patients seeking a gentler approach to treatment. As we continue to explore this desert of knowledge, we can confidently embrace new treatments that help us protect and preserve our precious sight.

Date :
  1. Date Completed 1981-02-19
  2. Date Revised 2019-10-31
Further Info :

Pubmed ID

7004425

DOI: Digital Object Identifier

10.1111/j.1442-9071.1980.tb01673.x

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・Side Effects of dipivefrin ophthalmic
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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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