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Antiestrogen treatment of breast cancer: an overview.

Author: ArafahB M, ManniA, PearsonO H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tamoxifen, a nonsteroidal antiestrogen, was found to be an effective and nontoxic endocrine therapy for women with Stage IV and II estrogen receptor-positive breast cancer. In a series of 113 patients with Stage IV breast cancer, tamoxifen induced objective remissions in 50%, lasting an average period of 21 months.
Paper Details　
Original Abstract of the Article :
The nonsteroidal antiestrogen tamoxifen has emerged as a highly effective, nontoxic endocrine therapy for women with Stage IV and II estrogen receptor-positive breast cancer. Tamoxifen appears to act by blocking endogenous estrogen action at the target tissue level rather than by suppression of circ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7044524

データ提供：米国国立医学図書館（NLM）

Antiestrogen Therapy: A Powerful Weapon in the Battle Against Breast Cancer

The fight against breast cancer is a constant struggle, and finding effective therapies is paramount. This research focuses on the use of antiestrogen therapy, specifically tamoxifen, in the treatment of estrogen receptor-positive breast cancer. The authors explored the mechanisms of action of tamoxifen and its effectiveness in various stages of breast cancer. They also compared the efficacy of tamoxifen to other endocrine therapies, such as hypophysectomy and aminoglutethimide.

The Promise of Antiestrogens

The research indicates that tamoxifen is a highly effective, nontoxic endocrine therapy for women with Stage IV and II estrogen receptor-positive breast cancer. The drug appears to block the action of estrogen at the target tissue level, leading to objective remissions in 50% of patients with Stage IV breast cancer. These findings are comparable to previous results with surgical hypophysectomy.

A Beacon of Hope for Breast Cancer Patients

This research provides valuable insights into the potential of antiestrogen therapy for breast cancer patients. It emphasizes the importance of considering this treatment option as an initial endocrine therapy of choice. The authors acknowledge the limitations of tamoxifen and highlight the need for exploring secondary endocrine therapies as needed. This research serves as a guide for navigating the complexities of breast cancer treatment, similar to traversing a vast and challenging desert landscape.

Dr. Camel's Conclusion

Tamoxifen stands as a beacon of hope for women battling breast cancer. Its ability to block estrogen action at the target tissue level makes it a highly effective therapy. This research offers valuable insights into the effectiveness of tamoxifen and its role in the fight against breast cancer. It's a reminder that even in the face of adversity, there are tools and strategies available to help us overcome challenges, like navigating the sands of a desert.

Date :
  1. Date Completed 1982-08-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7044524

DOI: Digital Object Identifier

7044524

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