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Double-blind crossover study of nabumetone versus naproxen in the treatment of osteoarthritis.

Author: CytrynE, PintensH, VerbruggenL A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nabumetone and naproxen, both nonsteroidal anti-inflammatory drugs, showed similar efficacy and tolerability in treating patients with rheumatoid arthritis. Both drugs improved morning stiffness, overall pain, and night pain, but no significant differences were observed in objective measures.
Paper Details　
Original Abstract of the Article :
Twenty-one patients entered a double-blind crossover study to compare nabumetone with naproxen. After a 1-week run-in period using a coated acetylsalicylic acid preparation, ten patients received nabumetone (1 g at night) over a period of 2 weeks, followed by 2 weeks on naproxen (250 mg b.i.d), whil...See full text at original site
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引用元：
https://doi.org/10.1177/030006058201000404

データ提供：米国国立医学図書館（NLM）

Nabumetone vs Naproxen: A Double-Blind Crossover Study

The treatment of osteoarthritis is a never-ending journey through a desert of pain and discomfort. This study seeks to find a new oasis of relief, comparing the effectiveness of two commonly prescribed medications: nabumetone and naproxen. Researchers embarked on a double-blind crossover study involving 21 participants, each experiencing the effects of both medications. The results reveal a remarkable similarity in effectiveness between the two drugs. Both nabumetone and naproxen demonstrated comparable improvements in morning stiffness, overall pain, and night pain, leaving patients with a sense of relief. The study also found that both medications were well-tolerated, offering a glimmer of hope in this often-grueling disease journey.

Two Paths to Relief: Nabumetone and Naproxen

The study indicates that both nabumetone and naproxen offer comparable relief for osteoarthritis. Both medications were effective in reducing morning stiffness, overall pain, and night pain. This suggests that patients have a choice in deciding which drug best suits their individual needs and preferences.

Finding an Oasis in the Desert of Osteoarthritis

This study demonstrates that patients suffering from osteoarthritis have two effective options for pain relief: nabumetone and naproxen. Both medications offer comparable efficacy and safety, providing a measure of hope and relief to those living with this chronic condition. Choosing the best option for you depends on your individual preferences and needs.

Dr. Camel's Conclusion

This research offers valuable insights into the efficacy and safety of nabumetone and naproxen for treating osteoarthritis. Both medications demonstrate comparable effectiveness and tolerability, suggesting that patients have multiple options for navigating the desert of osteoarthritis and finding relief from their pain. The study highlights the importance of individualizing treatment decisions to ensure the best possible outcomes for each patient.

Date :
  1. Date Completed 1982-12-02
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

7117678

DOI: Digital Object Identifier

10.1177/030006058201000404

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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