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Ephedrine as an anorectic: the story of the 'Elsinore pill'.

Author: HeyH, JuhlE, LarsenS, Malchow-MøllerA, QuaadeF, StokholmK H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the effects of diethylpropion, 'Elsinore pills' (ephedrine and caffeine), and placebo on weight loss in obese patients. Both diethylpropion and 'Elsinore pills' were significantly more effective than placebo in reducing weight after 12 weeks, with median weight losses of 8.4 kg and 8.1 kg, respectively. However, 4 patients in each treatment group experienced side effects like exaltation, tremor, and insomnia. Tremor was more frequent in the 'Elsinore pill' group.
Paper Details　
Original Abstract of the Article :
Obese patients, age 18-60 years, overweight 20-80 per cent, entered a controlled, clinical study comparing the effects of two anorectic drugs, ie a prescription containing ephedrine and caffein ('Elsinore pills') and diethylpropion, with placebo. All 132 patients were instructed in a 1200-kcal diet,...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7228474

データ提供：米国国立医学図書館（NLM）

The 'Elsinore Pill': Ephedrine's Anorectic Effect

This study delves into the history of ephedrine as an anorectic agent, a medication used to suppress appetite and aid in weight loss. It's like a quest through the sands of time to uncover the effectiveness of an ancient remedy for weight management. The researchers compared ephedrine and diethylpropion, another anorectic drug, to a placebo in a controlled trial.

Ephedrine: A Promising, but Not Perfect, Anorectic

The study reveals that ephedrine, a component of the 'Elsinore pills', demonstrated significant weight loss compared to placebo, but it was less effective than diethylpropion. While ephedrine shows promise, it also comes with potential side effects like tremor and insomnia, much like a camel that's been overfed and is feeling a bit jittery!

Navigating the Sands of Weight Loss

This research reminds us that weight management is a complex desert with many paths. While ephedrine shows potential, its side effects need to be carefully considered. It's essential to discuss potential risks and benefits with a healthcare professional to find the best approach for individual needs.

Dr.Camel's Conclusion

This study highlights the complexities of weight management, showing that even promising treatments can have side effects. It's essential to approach weight loss with a careful and balanced approach, just like a wise camel navigating a desert landscape.

Date :
  1. Date Completed 1981-07-09
  2. Date Revised 2014-06-03
Further Info :

Pubmed ID

7228474

DOI: Digital Object Identifier

7228474

Related Literature

Article Analysis
・Side Effects of diethylpropion
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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