Paper Details

  1. Home
  2. Paper Details

[Influence of antibiotics on leukocyte migration].

Author: CapozziC, De SimoneC, ManganaroM, MeliD, RiccaD

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of 13 antibiotics on human polymorphonuclear granulocyte (PMN) migration in vitro. Amphotericin B, cefalexin, cephaloridine, cefuroxime, chloramphenicol, dicloxacillin, gentamicin, and rifamycin inhibited PMN chemotaxis and/or random migration. Possible mechanisms include inhibition of intracellular respiratory enzyme synthesis, presence of inactive metabolites, and alterations of cyclic AMP, GMP, or membrane-bound divalent cations.
Paper Details　
Original Abstract of the Article :
Polymorphonuclear granulocytes play an important role in the immediate unspecific host response, and a depression of their functions can be found in many patients with severe or recurrent infections. Therefore administration of drugs causing such impairment in PMN function may be regarded as an addi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/7236361

データ提供：米国国立医学図書館（NLM）

Influence of Antibiotics on Leukocyte Migration

This research delves into the realm of immunology, investigating the effects of antibiotics on leukocyte migration, a crucial aspect of the body's immune response. The study aimed to assess the impact of 13 different antibiotics on the migration of polymorphonuclear granulocytes (PMNs), a type of white blood cell essential for fighting infections. The authors conducted in vitro experiments to understand how these antibiotics affect PMN migration under various conditions.

Impact of Antibiotics on PMN Migration

The study found that certain antibiotics, including amphotericin B, cefalexin, cephaloridine, cefuroxime, chloramphenicol, dicloxacillin, gentamicin, and rifamycin, can inhibit PMN chemotaxis and/or random migration in vitro. These findings highlight the potential for certain antibiotics to impair the body's immune response by interfering with leukocyte migration.

Considerations for Antibiotic Use

This research, like a desert explorer observing the delicate balance of the ecosystem, reminds us of the potential impact of antibiotics on the immune system. The study underscores the importance of carefully considering the potential consequences of antibiotic use, particularly in terms of their impact on leukocyte function and the overall immune response.

Dr.Camel's Conclusion

This study, like a camel caravan carefully navigating a delicate sand dune ecosystem, reminds us that antibiotics can have a profound impact on the immune system. The study underscores the importance of considering the potential effects of antibiotics on leukocyte function and the body's overall immune response.
Date :
  1. Date Completed 1981-08-27
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

7236361

DOI: Digital Object Identifier

7236361

Related Literature

Article Analysis
・Side Effects of rifamycin
SNS
PICO Info
in preparation
Languages

Italian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.