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The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation.

Author: BrownB W, HoppeR T, KaplanH S, KushlanP, RosenbergS A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study of 51 patients with non-Hodgkin's lymphoma found that all three treatment options (single alkylating agent chemotherapy, combination chemotherapy with CVP, or fractionated whole body irradiation followed by low dose involved field irradiation) had similar survival rates at 4 years (84%). While initial complete remission rates were similar, relapse was frequent, with only 25% of patients remaining relapse-free at 4 years. CVP was associated with the most acute complications, while whole body irradiation was associated with the most long-term hematologic depression.
Paper Details　
Original Abstract of the Article :
Between 1975 and 1978, 51 patients with favorable histology non-Hodgkin's lymphomas, pathologic stage III-IV, were treated prospectively on a randomized treatment protocol. Treatment options were single alkylating agent chemotherapy, combination chemotherapy with cyclophosphamide, vincristine, and p...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7259838

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Lymphoma Treatment: A Comparison of Treatment Strategies

Non-Hodgkin's lymphoma, a type of cancer affecting the lymphatic system, can be a challenging desert to navigate. This study explores different treatment strategies for patients with advanced-stage, favorable histology non-Hodgkin's lymphoma. The researchers aimed to compare the effectiveness of single-agent chemotherapy, combination chemotherapy, and whole-body irradiation, hoping to find the most effective path for patients battling this disease.

Finding Oasis in the Desert: Treatment Choices for Lymphoma

The study found that all three treatment options were associated with excellent long-term survival. While initial remission rates varied slightly, the overall survival outcomes were similar across the three treatment groups. The study also highlighted the importance of managing the side effects of each treatment approach, as certain complications were more prevalent with specific therapies. The researchers acknowledged the need for further research to refine treatment strategies and identify optimal approaches for different patients.

A New Compass for Navigating the Desert of Lymphoma

This study provides valuable insights into the treatment landscape for advanced-stage, favorable histology non-Hodgkin's lymphoma. The findings suggest that there are multiple effective treatment options available, offering patients a range of choices. The study also highlights the importance of carefully considering the potential side effects of each treatment approach, ensuring that patients are well-informed and receive appropriate care.

Dr. Camel's Conclusion

This study offers a valuable roadmap for navigating the desert of lymphoma treatment. The findings provide crucial information about the effectiveness and potential side effects of different treatment options, allowing patients and their doctors to make informed decisions. As we continue to explore new treatment modalities and refine existing approaches, we hope to find more effective and compassionate ways to help patients overcome this challenging disease and find a more fulfilling oasis.

Date :
  1. Date Completed 1981-10-29
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

7259838

DOI: Digital Object Identifier

S0006-4971(20)66500-4

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Article Analysis
・Effective treatment of lymphoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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