Timolol and epinephrine: a clinical study of ocular interactions.

Author: AshburnF S, BeckerB, GoldbergI, KassM A, PalmbergP F

Paper Details 
Original Abstract of the Article :
In a crossover design study, we assessed effects on intraocular pressure, pupillary diamter, pulse rate, and blood pressure over six hours of one drop of 0.5% timolol maleate and 2% epinephrine hydrochloride in one eye. Both eyes of each patient had been pretreated for one week with twice-daily appl...See full text at original site
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引用元:
https://doi.org/10.1001/archopht.1980.01020030480008

データ提供:米国国立医学図書館(NLM)

Timolol and Epinephrine: A Balancing Act in the Desert of Ocular Pharmacology

The [treatment of glaucoma] often involves the use of [topical ophthalmic medications], and [understanding the interactions between different drugs] is essential for [optimizing treatment efficacy]. This study investigates the [ocular interactions] between [timolol maleate] and [epinephrine hydrochloride], both commonly used [glaucoma medications]. Researchers examined the [effects on intraocular pressure, pupillary diameter, pulse rate, and blood pressure] in [20 patients] who received [timolol and epinephrine] in different sequences. Their findings shed light on the [potential for drug interactions] and the importance of [considering these interactions] when [prescribing medications].

A Camel's Perspective on Timolol and Epinephrine: A Dance in the Desert of the Eye

The [desert of ocular pharmacology] is a place where [drugs can interact] in unexpected ways. This study reveals that [timolol] can [reduce the ocular hypotensive effect] of [epinephrine], while [epinephrine] has [little impact on the pressure reduction] of [timolol]. These findings suggest that [pre-treatment with timolol] may require [adjusting the dosage] of [epinephrine] to achieve the desired therapeutic outcome.

The Desert of the Eye: Navigating Drug Interactions

This research underscores the importance of [considering drug interactions] when [prescribing ophthalmic medications]. The [unique characteristics] of the [eye] as a [drug delivery system] make it particularly susceptible to [interactions]. This study provides valuable information for [clinicians] navigating the [complex landscape] of [ocular pharmacology], ensuring that patients receive the [most effective and safe treatment] possible.

Dr. Camel's Conclusion

This study highlights the importance of understanding drug interactions in ophthalmic therapy. The findings demonstrate that timolol can reduce the ocular hypotensive effect of epinephrine, while epinephrine has little impact on the pressure reduction of timolol. This underscores the need for careful consideration of drug interactions when prescribing medications, particularly in the context of the unique characteristics of the eye as a drug delivery system.

Date :
  1. Date Completed 1980-05-14
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

7362504

DOI: Digital Object Identifier

10.1001/archopht.1980.01020030480008

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Languages

English

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